Protein Info for SMc03065 in Sinorhizobium meliloti 1021

Updated annotation (from data): ABC transporter for D-maltose/D-trehalose/sucrose, ATPase component (AglK)
Rationale: Specific phenotype on D-Maltose monohydrate; D-Trehalose dihydrate. Also mildly important for D-cellobiose utilization, which has its own ABC transporter, so the cause is unclear. Also reported to transport sucrose (PMID:10400573, PMID:12003938)
Original annotation: alpha-glucoside ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 362 PF00005: ABC_tran" amino acids 20 to 161 (142 residues), 118.6 bits, see alignment E=6.8e-38 PF17912: OB_MalK" amino acids 236 to 288 (53 residues), 41.4 bits, see alignment 4.5e-14 PF08402: TOBE_2" amino acids 282 to 353 (72 residues), 34.5 bits, see alignment E=3.6e-12 PF03459: TOBE" amino acids 296 to 352 (57 residues), 29.1 bits, see alignment E=1.9e-10

Best Hits

Swiss-Prot: 100% identical to AGLK_RHIME: Alpha-glucoside transport ATP-binding protein AglK (aglK) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K10235, alpha-glucoside transport system ATP-binding protein (inferred from 100% identity to smk:Sinme_0393)

MetaCyc: 54% identical to sn-glycerol 3-phosphate ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-34-RXN [EC: 7.6.2.10]; 7.6.2.10 [EC: 7.6.2.10]

Predicted SEED Role

"Alpha-glucoside transport ATP-binding protein AglK"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q9Z3R9 at UniProt or InterPro

Protein Sequence (362 amino acids)

>SMc03065 ABC transporter for D-maltose/D-trehalose/sucrose, ATPase component (AglK) (Sinorhizobium meliloti 1021)
MTGLLLKDIRKSYGAVDVIHGIDLDIKEGEFVVFVGPSGCGKSTLLRMIAGLEEITGGDM
FIDGERVNDVPPSKRGIAMVFQSYALYPHMTVYDNMAFGMRIARESKEEIDRRVRGAADM
LQLTPYLDRLPKALSGGQRQRVAIGRAICRNPKVFLFDEPLSNLDAALRVATRIEIAKLS
ERMSDTTMIYVTHDQVEAMTLADRIVVLSAGHIEQVGAPLELYERPANLFVARFIGSPAM
NVIPATITATGQQTAVSLAGGKSVTLDVPTNASENGKTASFGVRPEDLRVTEADDFLFEG
TVSIVEALGEVTLLYIEGLVENEPIIAKMPGIARVGRGDKVRFTADKAKLHLFDTNGQSY
RA