Protein Info for SMc02856 in Sinorhizobium meliloti 1021

Annotation: penicillin-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 767 transmembrane" amino acids 93 to 116 (24 residues), see Phobius details PF00912: Transgly" amino acids 149 to 315 (167 residues), 222.7 bits, see alignment E=2.4e-70 TIGR02074: penicillin-binding protein, 1A family" amino acids 153 to 670 (518 residues), 626.4 bits, see alignment E=2.3e-192 PF00905: Transpeptidase" amino acids 408 to 631 (224 residues), 106 bits, see alignment E=2.2e-34

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMc02856)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92T08 at UniProt or InterPro

Protein Sequence (767 amino acids)

>SMc02856 penicillin-binding protein (Sinorhizobium meliloti 1021)
MGTRSGPKGIFPSGMASGKSGQRIEPSFGGNDGDGGDLRVDASDRVAGGGSKPRRAKSPE
RGAKREKRGRRAGGRGSGRSGSGGGFFGLVRRLAYWCVVLGIWGAIGVGGLVLYYGARMP
SATSWSIPERPPNVKILAANGDIIANRGATGGEAVALEDMSPYIPQAVIAIEDRRFYSHF
GVDPLGLARAMLTNVMSGRMVQGGSTLTQQLAKNLFLSPERTLERKVQEVLLAFWLEQKY
TKDQILAMYLNRVFFGSNAYGVEAASRRYFNKSARDVNLGEAALLAGLLKAPSRLSPARD
PEAAEERAQLVLGAMREEGFISDSEIKTAMSQAPTRAKSFWSGAEHYVADMVMDQVPGMI
GEVTQDLVIDTTIDLTLEKKAEEVLAERLETEGGKLNASQAALVSIDGTGAIRALVGGRD
YAESQFDRASKAKRQPGSAFKPFVYAAALEIGRTPMSVRNDAPVRIGNWTPENYDQKYRG
EVTLADALANSLNTIAAQLVMEVGPQNVVKLAHRLGIDSDMQANASIALGTSEVTLVELT
SSYAPFMNGGFKATPHVIRRISTADGTVLYENTYDNPPRVLDPAIVSEMNRMMVRVLTDG
TGKNARLPGWEAAGKTGTTQSFRDALFVGYTSNLATGIWFGNDDGKFMKKVTGGGLPARA
WHDFMVAAHEGLSPSPLFGTTGVQPVFDEGGIAAAGEMPADGFDAGSPDVFPERPAGMDG
VESMDGMAAVDQVRPAEQAGGPIPPAGVGETTGGTRRTTLFDLLTGG