Protein Info for SMc02780 in Sinorhizobium meliloti 1021

Annotation: succinate-semialdehyde dehydrogenase [NADP+] protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 478 (460 residues), 564.3 bits, E=9e-174
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 30 to 476 (447 residues), 725.8 bits, E=1e-222

Best Hits

Swiss-Prot: 73% identical to DAVD_PSEAE: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 100% identity to smk:Sinme_3346)

MetaCyc: 73% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]

Predicted SEED Role

No annotation

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• L-lysine degradation X (4/6 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-lysine degradation I (3/7 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of L-lysine degradation (15/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20

Sequence Analysis Tools

See Q92TE2 at UniProt or InterPro

Protein Sequence (484 amino acids)

>SMc02780 succinate-semialdehyde dehydrogenase [NADP+] protein (Sinorhizobium meliloti 1021)
MNLKDPSLFRQAALVGETWIEADPKNAIEVNNPATGEIIGRVPKLGAADTRTAIEAAARV
QKEWAARTAKERSAVLRRWFELMIENKDDLGRILTMEQGKPLAEATGEIVYGASFIEWFA
EEARRVYGDLVPGHQKDKRILVMKQPIGVVAAITPWNFPNAMITRKAGPALAAGCAMVLK
PAAQTPFSAIAIAVLAERAGMPKGLFSVITGSAREIGAEMTSNPTVRKLTFTGSTEVGAE
LYRQSAATIKKLGLELGGNAPFIVFDDADLDAAVEGALIAKFRNNGQTCVCANRIYVQDG
VYEAFSDKLAQAVAKLKTGNGMEDGVILGPLIDQPALKKVEEHVADALAKGARVVQGGRR
HSLGGTFYEATVLADVTQAMAVAREETFGPVAPLFRFKDESDVIAQANDTEFGLASYFYA
KDLARVFRVAEALEYGMVGVNTGLISTAEAPFGGVKLSGLGREGSKYGIEEFMEIKYVCL
GGIA