Protein Info for SMc02361 in Sinorhizobium meliloti 1021

Annotation: cytochrome C-type biogenesis transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 381 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 95 to 114 (20 residues), see Phobius details TIGR03142: cytochrome c-type biogenesis protein CcmI" amino acids 2 to 118 (117 residues), 111.7 bits, see alignment E=1.2e-36

Best Hits

Swiss-Prot: 100% identical to CYCH_RHIME: Cytochrome c-type biogenesis protein CycH (cycH) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02200, cytochrome c-type biogenesis protein CcmH (inferred from 100% identity to sme:SMc02361)

Predicted SEED Role

"Cytochrome c heme lyase subunit CcmH" in subsystem Biogenesis of c-type cytochromes or Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P45400 at UniProt or InterPro

Protein Sequence (381 amino acids)

>SMc02361 cytochrome C-type biogenesis transmembrane protein (Sinorhizobium meliloti 1021)
MLFWILVAILTAAVAAVLLLPLMRAAEPLPSRHSHDIEVYRDQLGELARDREAGLIGSEE
AELARAEIARRMLSASAADQAVAERTPKRLLSNRLAQAFIFLCLPAVGLCLYLTTGSPGV
PAQPLAARLADPGDDVNILIAKAENHLALNPQDGAGWDLLAPIYMRHGRLDDAVAAYDRA
IRLLGPTPARMGGYAEALVAQAGGLVTAEAQNALQKALALDPDDPRSAFYLALGLKQEGK
HAEALAAFRKLAESSPADAPWLSLVNQHIAELAAAPAGPGPAAPGDPAPGDIAAAKEMNA
GDRQAMIRGMVDSLASRLKEDPANLEGWMRLVRSYVVLDQRDRAKDALHDGLRAFPATGE
QGKQLLALARELGIDAGGEAE