Protein Info for SMc02292 in Sinorhizobium meliloti 1021

Annotation: type I restriction enzyme R protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1065 transmembrane" amino acids 659 to 680 (22 residues), see Phobius details PF04313: HSDR_N" amino acids 23 to 226 (204 residues), 155.8 bits, see alignment E=2.7e-49 TIGR00348: type I site-specific deoxyribonuclease, HsdR family" amino acids 29 to 725 (697 residues), 489.1 bits, see alignment E=1.2e-150 PF18766: SWI2_SNF2" amino acids 289 to 515 (227 residues), 250.1 bits, see alignment E=4.1e-78 PF04851: ResIII" amino acids 296 to 451 (156 residues), 65.7 bits, see alignment E=9.7e-22 PF11867: T1RH-like_C" amino acids 733 to 1031 (299 residues), 124.8 bits, see alignment E=1e-39

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 100% identity to sme:SMc02292)

Predicted SEED Role

"macromolecule metabolism; macromolecule degradation; degradation of dna"

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92S35 at UniProt or InterPro

Protein Sequence (1065 amino acids)

>SMc02292 type I restriction enzyme R protein (Sinorhizobium meliloti 1021)
MADTPKDIHYGFPEGTRATLTGFSEDGLVEKPAIALLESLGWSHLNLYDETFGVDGSSFR
DTLRDPYLTKTLRTALARLNPGLPQDALDLAFDALTQDRASMVPMAANREVLELVRDGVD
VEYRDDDGGMAKERVRVIDWRDLGANEFTLISQVWISGELHRRRTDLIGFVNGVPLLFIE
LKAGHRRIEDAYRDNVRDYRDSIPQLFRPNGFVLVSNGLDTRIGASAYSPWDTYKEWKRI
DDETEPGRVSLETAIRAAATPERLIDLVENFLIFEETKDGLVKKIAQNHQFLGVNKAVQA
VVNLGENRGKLGVFWHTQGSGKSLSMLTFTRKVLRAIPGSWTFVIVTDREELDKQISDVF
AACGAVTKDVREVRAGSKEHLKTLLRGNERYVFTLIHKFGTAKGETFPVLSERSDIIVIA
DEAHRSQYDTLAANMRRALPNAAFIGFTGTPLMAGEEKTRDVFGDYVSTYTYQQSTEDGA
TVPLYYENRIPELEFANESFAEDLEAVIEEADLDEEQERELEKRLGTQYHLITREDRLDR
IAEDLVRHFVGRGYRGKAMFVAIDKATAVRMYDKVRRAWDAEIARRVAALGSAPADQREA
QAAVIAFMRETDMAVVVSQGQNEIADMEAKGLDIRAHRRRMIEEDLDERFKKGSDPLRLV
FVCAMWITGFDVPTCSTIYLDKPMKNHTLMQTIARANRNAPGKKAGLIVDYVGIFRNLEK
ALAIYAVGGATNAKPIEDKSALVEDLAQAIDEALAFCRARDVDPGAILEVAGFDRLRRLG
DAVEALNGTDPERRTFLALASNVWSTFKAVLPDARAEPYRKISAAIEVIAERIRSLTERP
DISEVSGKIEALLDNSIAGVEITAPILEDGDTTGLFDLSRIDIERLRAMFDTGNRQRTET
QRLRRAVEDRLEDMAARNPTRRGLVERFEALVAQYNAGSLTAADFFNQLLALVGDMNTED
QRAIRQGLTEEELAIFDILTQPEPKLGPEDEDLVKRVAKSLLEKLKAEKLVLDWRLKERA
KAAVKATIQQLYDDGLPQAYGQGVFDEKVERTYQWVFEKYSGGSV