Protein Info for SMc02273 in Sinorhizobium meliloti 1021

Annotation: fatty acid synthase transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2200 2400 2504 transmembrane" amino acids 1850 to 1865 (16 residues), see Phobius details amino acids 1877 to 1896 (20 residues), see Phobius details amino acids 1908 to 1925 (18 residues), see Phobius details amino acids 2112 to 2131 (20 residues), see Phobius details PF00109: ketoacyl-synt" amino acids 3 to 247 (245 residues), 258.5 bits, see alignment E=4.3e-80 PF02801: Ketoacyl-synt_C" amino acids 257 to 373 (117 residues), 116.9 bits, see alignment 3.2e-37 PF16197: KAsynt_C_assoc" amino acids 375 to 486 (112 residues), 57.1 bits, see alignment (E = 1.3e-18) PF00698: Acyl_transf_1" amino acids 527 to 831 (305 residues), 228.9 bits, see alignment E=6.5e-71 PF21089: PKS_DH_N" amino acids 905 to 985 (81 residues), 50.4 bits, see alignment (E = 1.2e-16) PF14765: PS-DH" amino acids 1026 to 1164 (139 residues), 67.6 bits, see alignment 5.9e-22 PF08240: ADH_N" amino acids 1789 to 1855 (67 residues), 26 bits, see alignment (E = 4.1e-09) PF00107: ADH_zinc_N" amino acids 1916 to 2026 (111 residues), 78.2 bits, see alignment (E = 3.3e-25) PF13602: ADH_zinc_N_2" amino acids 1948 to 2087 (140 residues), 77.9 bits, see alignment 8.8e-25 PF08659: KR" amino acids 2111 to 2288 (178 residues), 181.7 bits, see alignment 8e-57 PF00106: adh_short" amino acids 2113 to 2275 (163 residues), 35 bits, see alignment 6.4e-12 PF00550: PP-binding" amino acids 2399 to 2461 (63 residues), 32.4 bits, see alignment (E = 5.3e-11)

Best Hits

Predicted SEED Role

"Capsular polysaccharide biosynthesis fatty acid synthase WcbR" in subsystem Capsular heptose biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92S51 at UniProt or InterPro

Protein Sequence (2504 amino acids)

>SMc02273 fatty acid synthase transmembrane protein (Sinorhizobium meliloti 1021)
MTVEIIGRACLAPGAKSPQALFKILRQGKCTVTRVPSDRWDLARFWHPVMGTPGKTYSFA
AGVLDHIYDFDPAVFGMSQREAMYMDPQQRVLLQLAWRALEDANISVASLHGENVGVYVG
ASSLDHANLTVDDPAAAGPYFMTGNTLSIVSNRISHVFGLSGPSMTVDTACSSSLVALDQ
AMRALNAGEIDTAIVGGVNILAHPLPFVGFAQARMLSPEGLCRAYDNDGAGYVRAEGGVV
FVLRRTDRAQRERDRSYARIVASGVNSAGRTNGISLPSREAQANLLRMIYEGNGIDANQV
AFVEGHGTGTKVGDPAEVWSIGTVIGAKRRAPVPIGSIKSNIGHTEPASGLFGMMKAVLA
LENNYLPASLHFETPNEQIDFDGLNVRVTANPIELLKGKRARLAGINSFGFGGANAHVVI
SDPDPAQAEKAATSPAGHVFLASAHTASSLENLLRDYKAAFAGATKEETRAIVAASGANR
THMRHRFAARSDHPEDIVRAIANHLEKPGSDIGETGEAAAKEAKVAFVFSGNGSQWAGMG
VEAFRENLHFRQSFTSVSALFRFHSDIVLTDLLTDPELDRKLADTKVAQPLLFAIQAALS
DSLVAMGIKPTAVFGHSVGEIAAAYAAGALSLVDAVSIVAKRSLHQDLLAGQGTMAAVML
GEEAAKAFAAERGLDDVCVAAINAHNSVTISGPANEISAFRDAARKAKIPVQILDINYPF
HHPIIDRAKEAFLSDIPDIAPRRTELAYLSTVTGAALDGTALDPDYWWKNVREPVRFQAA
AEAALDLGCMLFIEISPRPILGSYVKETIKQAAVPASVVATLLRDAGANGHDPISASMAR
AVAHGAAVDRSRVYGKRDAFIELPALPFEPVELRPAATTDATDLFGRSAKPYRLNGWRGD
PNAGSWKNHVDAHLFPDLAEHVVDGKAILPGSGFIEIAVSAAQQYHGSDEVEITNLEIVR
PLELSDSRIMELSTILSPETGDIEIRSRERLSEDDWTVHAVARSRKPLPTTSNDCPSTKG
LAKTATVTAAKAYETAKQFGLDYGPQFQLLSKAVAYGDRLIDVELKHPRASGHPHVTYAL
HPISVDATFHGLVALFDRFTGDRGGAPYIPVRFGSVRVVNAGRPIARATIEIERVSANSI
KARFHFFDETGVAIAHFEDCRFRRTYLRKHKTLEGLSFHYEAVLSDVVMPGTKVATAMPA
TLAEPIDDNGVDNATLLFNAAIYRACQEIALKLGRGTATVRGDALPGDFAFQCFLTSCLL
TLEDAGLCEHQNGNWKVAREFSLPTVPEILGELYGDRPDRAVEAVLVNNAYAEALSRLDA
LLGPVRAGDDAVSFNAGFISEATLDHQAVHSVASRSRMDQVLHTVEHVLAAQPAGARLRL
IELGSVSAGFSRRLADLAARNGAALSIFEPRDNAQRNLEIAFEEDAHVRVLKKSEFADIG
PFDLAVSASDNLYQVIEEESGVRTALRSMPPGSGLVAAVSAPSIFADFALGLSGGWFERS
QTAEFPIGRIAAVPHWQKCLADLDLGDVVVTDRECPHGNTILIEARGTAAAGAGAEPGET
TTPYLLIETATAQKPVAAGGRSAAPVRVTGDLAADMATLRAALEAMGDRPVRAVFMSEAE
RAVGDGSALLQTRVLALSAFAEALKQHLAGVEPEGDDRPRLVLVAPGGAPLSASAGSGLN
SGLWAFARVLQNEYEFIDVHTLDLAGDADIGRKDMLAAALPLLTVSGQNRGWLLDRKTGL
LSELRAVPGATNKADGKTNAFAAATIRQRVSSQVASIAWEEASVPEPGPNEVVVAVAATG
LNFRDVMWAMGLLPEEALEDGFAGATIGMELSGHVVAVGEEIDDLAVGDAVMAIASAAFS
THAVVARAGIAKLPRALSPVAAATLPVAFLTAYYAIVELGRIQAGETILIHGAAGGVGLA
ALQVAKLKGAKVIATAGTREKRRFLTMLGADHVFDSRSLGFVEDVRSVTGGEGVDLVLNS
LFAEAMEQSLSLVKPFGRFLELGKRDYYADSKIGLRPFRRNVSYFGIDADQLLVNAPDLT
RRIFMEIGALFEEGKLTPLPYRAFDYDEIGNAFRLMQNAGHIGKIVVLPPVAGRHEVTAK
AVRGMKVDPDGVHLVVGGIGGFGLVAANWLVEKGARRIALCSRRGQPDAETRAMIERWQN
GGVAASVHACDITDAAAVETLLATLRSEAPLRSVVHAAMVLDDALIGNLSRERNRPVIET
KAKGAAILDRLTRGDRLDNFILFSSATTLVGNPGQANYVAANGYLEGLARARRQEGLAGL
AVGFGAIADAGYLTQNADVNDLLAKRIGKTALKAQVALDMVENHVAADPGTVDAAVVMIS
EIDWTAARNLPVARNALFEVILRSADQHAAGAEGTTMDLVAMIEGKSPQEAEDILFDLVA
GEIAAILRVSKDTVTRGKILKEIGLDSLMAVELGMSFQQNTGFDMPLSGVADNTTVGDIA
RKLHEKVSKRDQGNENENEAGDDKLVTELTQRHVGADKEKALSQ