Protein Info for SMc02249 in Sinorhizobium meliloti 1021

Annotation: sensory transduction histidine kinase transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1168 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 41 to 64 (24 residues), see Phobius details amino acids 70 to 89 (20 residues), see Phobius details amino acids 116 to 135 (20 residues), see Phobius details amino acids 162 to 181 (20 residues), see Phobius details amino acids 193 to 220 (28 residues), see Phobius details amino acids 246 to 264 (19 residues), see Phobius details amino acids 285 to 310 (26 residues), see Phobius details amino acids 331 to 363 (33 residues), see Phobius details amino acids 385 to 405 (21 residues), see Phobius details amino acids 413 to 438 (26 residues), see Phobius details amino acids 445 to 466 (22 residues), see Phobius details amino acids 473 to 490 (18 residues), see Phobius details amino acids 497 to 517 (21 residues), see Phobius details PF12860: PAS_7" amino acids 650 to 759 (110 residues), 111.8 bits, see alignment E=4.3e-36 PF00512: HisKA" amino acids 801 to 865 (65 residues), 38.6 bits, see alignment 1.8e-13 PF02518: HATPase_c" amino acids 910 to 1018 (109 residues), 80.7 bits, see alignment E=2.2e-26 PF00072: Response_reg" amino acids 1044 to 1154 (111 residues), 36.9 bits, see alignment E=7.5e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMc02249)

Predicted SEED Role

"Na+/proline symporter / Sensor histidine kinase PrlS"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92S73 at UniProt or InterPro

Protein Sequence (1168 amino acids)

>SMc02249 sensory transduction histidine kinase transmembrane protein (Sinorhizobium meliloti 1021)
MLSGSVIFASAFAYLLLLFAVASYGDRRARRNEIAAKGRPLVYALSLAIYCTSWTYFGGV
GLAAERGLEFTGIYIGPILMFTLGMPLIRRIVRLAKTEKLTSVADFVAARYGKNPAVAAI
VALISLVGAIPYIALQLKAVSSSVATMIDTSDYGIGSGENFVDLPLLVTLFLACFAIVFG
TRHTDATEHQDGLILAIAMESVVKLVAMLTVGVYIVFVLFGGPANLWAEAQQSVTVIAAL
EYQTPVARWILMIALSAFGIIMLPRQFHVTVVENRTDNELRTAGILFPLYLIAINAFVLP
IAIAGILTFSGSGNADLYLLALPLAGDVPLVTLFTFIGGFSAATAMVIVASVALSIMVSN
DIVMPVFLRRRLGTRGSLQEDMAGTLLNIRRTAIFVVLFLGYGYYRAADISAGLASLGLL
SFAAIAQMAPALLGGLVWRQANARGAIAGMVSGFLVWAYVLFLPSLGGPDNSHIASTVLS
FLLPFTDLFSGAQSDPLVNATALSMLVNVAAYIVGSLTRAPKPLERFQAGVFITRRSRTE
RTFRGRKTKVTVRDLKTTIGRYMGEERMQRSFHTYEQQSGRWLDDNASADMALVHFSEQL
LGSAIGSSSARLVLSLVLQRMDDTSSDTAWLLDQASEALQYNQDMLHTALSQMDQGIAVF
DNANNLIIWNRRFRELMDLPEAAGQVGFPLADIVAILARRGDVRKDEEKALIANFLTLDK
PFLLELAGGARIVEVRSNAMPDKGIVTTYTDITQRVAADMALKQANETLELRVAERTGEL
TRVNRELGEARAAAEEANIGKTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQ
NIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDELLRRIETDFAPMARAKDIELVI
MPTSLAARSDPNLLRRLVQNLVSNAIKYTLRGKVLVGVRRHGQTATIEVLDSGIGIPSSK
FRTIFKEFARLEEGARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKS
AGGRLKPQSVAAAKTSEALAGLNVICIDNEPKILEGMALLLGGWGCSVTTAESLAGCTEM
APGRLGVRPDAIIADYHLGDGTGVEAIAAIRGLWQESIPALMVTADRSPEVRGAAERDGV
SLQHKPVRPAALRAWLTQLAAAGRAAAE