Protein Info for SMc02124 in Sinorhizobium meliloti 1021

Annotation: nitrite reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03460: NIR_SIR_ferr
  • amino acids 52 to 110 (59 residues), 65 bits, 4.1e-22
  • amino acids 330 to 398 (69 residues), 48.9 bits, E=4.6e-17
• PF01077: NIR_SIR
  • amino acids 119 to 272 (154 residues), 164.9 bits, E=1e-52
  • amino acids 410 to 530 (121 residues), 47.1 bits, E=1.8e-16

Best Hits

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 100% identity to smk:Sinme_1272)

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.2

Sequence Analysis Tools

See Q92Q78 at UniProt or InterPro

Protein Sequence (557 amino acids)

>SMc02124 nitrite reductase (Sinorhizobium meliloti 1021)
MYRYDEFDHAFVSARVEQFRDQVQRRLSGELAEDAFKPLRLMNGVYLQLHAYMLRVAIPY
GTLSSRQMRMLAHIARKYDRGYGHFTTRQNIQYNWPRLSDTPDILQELASVEMHALQTSG
NCIRNVTADHFAGAAADEVADPRPYAEILRQWSSVHPEFSFLPRKFKIAVTGAERDRAAI
QVHDIGLHLKKDENGKLGFAVYVGGGQGRTPLIAKKIRDFLPEEDLLSYTTAIMRVYNLH
GRRDNKYKARIKILVHETGAEELARQVELEFANLKDTELKLPDADIQAIAAYFAPATLPN
RTEGWGSLARWKKADPEFARWVHQNVQPHKHPDYGMVTISLKPIGGIPGDASHEQMDAVA
DIAEEYAFDEIRVSHEQNLILPHVALADLEPVYRALVAAGLATANAGLITDIIACPGLDY
CALANARSIPVAQEISNRFGSPERQAEIGELKIKISGCINACGHHHVGHIGLLGVEKKGA
ELYQITLGGSGDEHTSIGEIIGRGFEPERVTDAVETIVDTYLGLRRDKSETFLEAYRRVG
PQPFKDALYGGGAQAAA