Protein Info for SMc02116 in Sinorhizobium meliloti 1021
Annotation: salicylate hydroxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00480, salicylate hydroxylase [EC: 1.14.13.1] (inferred from 100% identity to sme:SMc02116)Predicted SEED Role
"Salicylate hydroxylase (EC 1.14.13.1)" in subsystem Salicylate and gentisate catabolism or Salicylate ester degradation (EC 1.14.13.1)
MetaCyc Pathways
- methylsalicylate degradation (2/2 steps found)
- salicylate degradation I (1/1 steps found)
- superpathway of salicylate degradation (5/7 steps found)
- chlorosalicylate degradation (2/7 steps found)
- naphthalene degradation to acetyl-CoA (2/12 steps found)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate (7/42 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Bile acid biosynthesis
- Fluorene degradation
- Naphthalene and anthracene degradation
Isozymes
Compare fitness of predicted isozymes for: 1.14.13.1
Use Curated BLAST to search for 1.14.13.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92Q69 at UniProt or InterPro
Protein Sequence (387 amino acids)
>SMc02116 salicylate hydroxylase (Sinorhizobium meliloti 1021) MQKADPVAIVGAGIAGLTAALCLARKGFRTDIFEQADALEEAGAGLQLSPNASRILIELG LLPALERVWNEPEAISLTDGRSLRPLASVPAGARARERWGAPYGVLHRASLQTILLDAVR AEPLCRLHLGRRIADDPRTVITEASKRSPAAIIGADGIWSRIRSSVAGAGTVRFSGNVAW RFTLPRTRVPACLSQDRVTAFLAPKAHLVAYPIRKIDGFNFVAIVAGRASGETWEGRESG DRRREFEAAFRDWHPDLRSSLGHAGSATYWPLCTVEDGAWHNGRDTILIGDAAHALTPFA AQGAAMAIEDARELARCMADSPDLPSAFARYEDARRVRIGRVRKRAAFNSFAYHAAGPVR IARNLVLSFKKPEALAADFDWLYGYGS