Protein Info for SMc01992 in Sinorhizobium meliloti 1021

Annotation: alcohol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 PF08240: ADH_N" amino acids 26 to 136 (111 residues), 88 bits, see alignment E=7.5e-29 PF16912: Glu_dehyd_C" amino acids 168 to 342 (175 residues), 41.6 bits, see alignment E=2.1e-14 PF00107: ADH_zinc_N" amino acids 177 to 304 (128 residues), 74.3 bits, see alignment E=1.8e-24 PF13602: ADH_zinc_N_2" amino acids 214 to 330 (117 residues), 31.2 bits, see alignment E=8.1e-11

Best Hits

Swiss-Prot: 100% identical to XYLD_RHIME: Putative D-xylulose reductase (R02526) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_2575)

MetaCyc: 58% identical to xylitol dehydrogenase (Morganella morganii)
D-xylulose reductase. [EC: 1.1.1.9]

Predicted SEED Role

"Xylitol dehydrogenase (EC 1.1.1.9)" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization (EC 1.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92MT4 at UniProt or InterPro

Protein Sequence (346 amino acids)

>SMc01992 alcohol dehydrogenase (Sinorhizobium meliloti 1021)
MAKALVLEKKGQLSLRDIPVRRDLSPTDVLIGIRTVGVCGSDVHYYTHGKIGPFVVNEPM
ILGHEAAGVVLEVGSQVRHLKKGDRVCMEPGIPDLSSRSSKLGIYNVDPSVRFWATPPVH
GCLTPEVVHPAAFTYRLPDHVSFAEGAMVEPFAIGVQAALRAGIRPGDVGAVMGAGPIGM
MTALAALAGGCSKVYVADLAQPKLDVIGAYEGIETINVRQQAVSEALAGATGGWGADVVF
ECSGAAPAILALPSLARPGGTVVLVGMPVEPVPFDIVGMQAKELRIETVFRYANVYDRAI
ELIASGKVDLKPLISATIPFDESIAAFDRAVEARPTDVKIQIEMPA