Protein Info for SMc01623 in Sinorhizobium meliloti 1021

Annotation: erythritol kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 525 PF00370: FGGY_N" amino acids 5 to 249 (245 residues), 138.7 bits, see alignment E=2.6e-44 PF02782: FGGY_C" amino acids 290 to 457 (168 residues), 79.6 bits, see alignment E=2.9e-26

Best Hits

Swiss-Prot: 55% identical to ERYA_BRUA2: Erythritol kinase (eryA) from Brucella abortus (strain 2308)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_2215)

MetaCyc: 55% identical to erythritol kinase (D-erythritol 1-phosphate-forming) (Brucella abortus)
RXN-17770 [EC: 2.7.1.215]

Predicted SEED Role

"Erythritol kinase EryA (EC 2.7.1.27)" in subsystem Erythritol utilization (EC 2.7.1.27)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.27

Use Curated BLAST to search for 2.7.1.215 or 2.7.1.27

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92NH0 at UniProt or InterPro

Protein Sequence (525 amino acids)

>SMc01623 erythritol kinase (Sinorhizobium meliloti 1021)
MRDILIGIDAGTSVIKSVAFDLGGRQLAMTAVPNSYEAVGRTGSVQELRRTWTDTVKTLV
ELSARIENLPGRVAAIAVTGQGDGTWMIDREGEPVGKGWLWLDARAGAIVERLRAESGDA
ERFSRTGSGLAACQQGPQLRWMKDHAPEMLQGAATAFHCKDWLYFNLTDKRATDPSEANF
TFGDFRKRQYSDEVIDFLGLNELKHLLPEIVDGASTHHPLSAAAAAATGLPAGTPVVLGY
VDVVCTALGAGLYDPGTDTGCSIIGSTGMHMRLAAGADDVRLNQDHTGYTMCMPIPGTYA
QMQSNMAATLNIDWILQFAGGLLKGMGIEKSKNDLLAHVDGWLSEANETPLLFQPYISEA
GERGPFVDASARASFVGLSINHGFGDMVRAVFDGLAFASRDCYAAMGPLPACVRLSGGAA
RSASLRRILGGALGASIQTSEREEAGAAGAAMIAAVSLGIYPSMADCVREWVRPHHRPAE
PADEELARRYDALFPAYKQSRLALQPVWHALSHAAGTGNQQERPQ