Protein Info for SMc01491 in Sinorhizobium meliloti 1021

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1029 transmembrane" amino acids 682 to 699 (18 residues), see Phobius details PF00211: Guanylate_cyc" amino acids 38 to 203 (166 residues), 30.2 bits, see alignment E=3.4e-11 PF13191: AAA_16" amino acids 232 to 414 (183 residues), 70.8 bits, see alignment E=2e-23

Best Hits

Swiss-Prot: 100% identical to Y2095_RHIME: Uncharacterized protein R02095 (R02095) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 100% identity to sme:SMc01491)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1) / Guanylate cyclase (EC 4.6.1.2)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1, EC 4.6.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1, 4.6.1.2

Use Curated BLAST to search for 4.6.1.1 or 4.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q52999 at UniProt or InterPro

Protein Sequence (1029 amino acids)

>SMc01491 hypothetical protein (Sinorhizobium meliloti 1021)
MREWCMLRESRTNTPRRAAERGKRPGGSSVRGGERRIVTALCYDLVGSTDLMHVMDIEDY
QELMSAFQLASKQAIASHSGVMQHEAGDGGVALFPIELEAKDAASLAIRAGLGIVEACKR
VGREAGQDDLQVRVGIATSVALVLEGSREGWTREPVTGAALAMAARLQAITAPNSVLVSE
ETRHLAGRSYAFVFQGSKELKGFAAPEKVWRALGHKVGVDRFYAFGRMGGPLINRENELN
TIGQLWDGVLAGQGSVVLIQGDAGIGKSRLLREIRRRTRAKRSKLLFFQCLPGGFRSTLH
PLLNNLPEAVSGSAGQMGPTAAAVAALFERNGIRDPAVVDVFSYLLGAQGSRLQSNEDPK
AIREKAHRALLRALEAVCRRGPAVVAVEDVHWIDPTSRDLLGEAARIIAKFPVLLVTTSR
PSYASEWLDAANPTRLALRPLDSDETRLAIKAKWPEHRLALLPDLFDATERISGGVPLFI
EEICQWVSQNVEPDTMRLSESANPSHVSAFESILESRLQQLGTAREVARAAAVAGTQVTL
PLLRALLPDFGKSALANAADTLCETGFLTRIRVPGRTAYGFRHTLIQETIYNAVLRKQRQ
VLHRRLFTAVNQNRGMAAWIDTGALAEHAERAGLVEEAVPLFIAAGKESSSRSAMIEARQ
FLEHALDLCGQMSESDTAEALKLLALTALGPILIGTVGLSSEPARRLYEDAVEIARRRPM
SEQSQWFPIYWGWWLTGQDFRVMHDRALEVRSMLSKANEPEIQLQVNHCIWAIDFNLGRH
RETQDAIKAGLALYDEKRAKESRTEFGGHDAKVCGLGQLALSLWLTGRTKASDAALSRMI
AFTDRIAHAHSKAHSLDTEAVSAFYRDDFERLTEVSARMADFAKRHKMQSLSGQSLLFSG
WAEAHRTGLASGHARFQNGLSLLRELGAVADLPIYLCMHATLLGLAGKIEPAIEVVNEAI
GRGEETGHAYWLAELHRCRAILRARAGERKDAVAADLRCAVEIAESQGATALTRRARHSM
RELGIVIGR