Protein Info for SMc01458 in Sinorhizobium meliloti 1021

Annotation: transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 398 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 79 to 381 (303 residues), 239.1 bits, see alignment E=2.9e-75 PF16576: HlyD_D23" amino acids 102 to 300 (199 residues), 99.4 bits, see alignment E=3.8e-32 PF13533: Biotin_lipoyl_2" amino acids 102 to 146 (45 residues), 32 bits, see alignment 1.6e-11 PF13437: HlyD_3" amino acids 199 to 299 (101 residues), 57 bits, see alignment E=5.8e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMc01458)

Predicted SEED Role

"Membrane fusion protein of RND family multidrug efflux pump" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92NP6 at UniProt or InterPro

Protein Sequence (398 amino acids)

>SMc01458 transporter (Sinorhizobium meliloti 1021)
MRFWNQLAISVVVLAVGGAAWVRLAPGAGETLAAIGVSQPLIDALSGPQGGEGARGGSGD
SERGQGRRSGFAEAPLVVVKPAERAVVNDRLNAIGNGEAIRSVTVTPTATGNLTEILVKS
GDRITEGQVIARLDSDDQMIAAEQARLTRDSAREKVERYRNLSTARAVTAVEVRDSEIAL
QAAELALKTAELDLKRRDIVAPSKGVVGIITVNIGDYVTTSTPIAVVDDRSQILVDFWVP
ERFAGKISVDQPVTASAIAQPGRALQGVVHAIDNRLDPESRTLRVRARLENPDDMLRAGM
SFSVTVAFDGDRYPTVDPLAIQWSSEGSFIWRVKGDKSERVPIKIIQRNPDKVLVDAELA
EGDRVVTEGVQRLRDGGVVRIAGEPAAEAEQKVAGDAQ