Protein Info for SMc01457 in Sinorhizobium meliloti 1021

Annotation: transport transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1044 transmembrane" amino acids 29 to 48 (20 residues), see Phobius details amino acids 349 to 366 (18 residues), see Phobius details amino acids 373 to 393 (21 residues), see Phobius details amino acids 399 to 423 (25 residues), see Phobius details amino acids 443 to 464 (22 residues), see Phobius details amino acids 476 to 499 (24 residues), see Phobius details amino acids 532 to 555 (24 residues), see Phobius details amino acids 862 to 880 (19 residues), see Phobius details amino acids 888 to 909 (22 residues), see Phobius details amino acids 915 to 939 (25 residues), see Phobius details amino acids 963 to 984 (22 residues), see Phobius details amino acids 992 to 1018 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 21 to 1018 (998 residues), 892 bits, see alignment E=4.9e-272 PF03176: MMPL" amino acids 302 to 500 (199 residues), 25.2 bits, see alignment E=7.8e-10

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 69% identity to ara:Arad_2952)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92NP7 at UniProt or InterPro

Protein Sequence (1044 amino acids)

>SMc01457 transport transmembrane protein (Sinorhizobium meliloti 1021)
MNIGMGGHQPGGGQGGKTGFTALFIRRPIFALVVNTLIVVAGLAAWNGVEIRELPQVDQP
VVSVTTEFDGASPETIDREVTSVIEGAVSRVQGIKGISSSSSFGRSRVTLEFSDTTDIGQ
AANDVRDALGRITGQLPDDADEPRIVKADSDSQPIMRLALTSDTMSMDDMTLLVENEISD
RLAAVEGVADVTVYGDQEKIFRIDLNQAKLAGRGVTVANLREALSDASYDVPAGSLTSAS
QDISVRATADLQTPEQFENLMLGNNVRLRDVATVTLGPDTGTSALRSNGREGIGLGIIRQ
AQSNTVDISEGVRSVVDAISSDILPTGTELKITSDDAVFINGAIHEVEIALFVAVFIVTL
VIYLFLLDWRATLIPTITMPIALIGTVAAIYLAGFSINILTLLAIVLATGLVVDDAIVVL
ENIVRRRAEGLGPRAAAVHGTLEVFFAVLATTATLAAVFVPLSFLPGQTGGLFREFGFVL
AFSILLSSFVSLTLCPMLASRMLTKEPHEHDGVMQRFGRRASAFYRVTLRACLNAPLIVF
AVAAFFTAAGALGFLTLKSELTPNEDRSQVMLRINAPQGVSLEYTQAQLRRIEEGLQPLL
KSGEISNVFSISGQGGSANSGFMVLTLAPWEERERTQGQIVADINRATSKIPSVRAFTIQ
ANSLGIRGAGSGLQVALVGNDYTKLGDAAAKLVRAMEDTGRFENVRLNYEANQAQLSVTI
DRERASDLGVDIGGLSWALQAMLDGSSVVDIFVEGEAYPVKLLSSTEPLNDPTDLQNIFV
KAGDGRIVPMSSIATVEEKAVAPQLSRESQLRAVSLSAGLKSDLALGEALSMVEEMAEPL
LPPGSRVMPLAEAATLDENANGLFVTFGFALVIIFLVLAAQFESFVSGLIIMSTVPLGLA
CAVFAMIVTGNTLNIYSQIGLVMLVGIMAKNGILIVEFANQLRDRGQDVRSAIENAANIR
LRPVMMTMIATVVGAVPLVLASGAGAEARIALGWVLVGGLGLAVVVTLYLTPVAYLVIAR
FTKPHADEERKLQEEMNAAEVLKI