Protein Info for SMc01288 in Sinorhizobium meliloti 1021

Annotation: adenylate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01351: adenylate kinase
  • amino acids 2 to 191 (190 residues), 208.5 bits, E=4.5e-66
• PF13207: AAA_17
  • amino acids 6 to 129 (124 residues), 94.6 bits, E=1e-30
• PF00406: ADK
  • amino acids 6 to 168 (163 residues), 188.8 bits, E=9.9e-60

Best Hits

Swiss-Prot: 100% identical to KAD_RHIME: Adenylate kinase (adk) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K00939, adenylate kinase [EC: 2.7.4.3] (inferred from 100% identity to sme:SMc01288)

Predicted SEED Role

"Adenylate kinase (EC 2.7.4.3)" in subsystem Purine conversions (EC 2.7.4.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of purine nucleotide salvage (13/14 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.3

Sequence Analysis Tools

See Q93FE6 at UniProt or InterPro

Protein Sequence (192 amino acids)

>SMc01288 adenylate kinase (Sinorhizobium meliloti 1021)
MRLIFLGPPGAGKGTQAKLLTERYGIPQLSTGDMLRTAVAQATEVGKRAKAVMDAGQLVS
DEIVNEIVSDRIDSADCARGFILDGYPRTVPQAVALDRMLEEKGLKLDAVIELKVDEAAL
VRRMENRVTETVAAGGTVRSDDNPEAFRRRLQEYREKTAPLSEHYARTGRLKTVDGMADV
HTVTAEIEKILA