Protein Info for SMc01235 in Sinorhizobium meliloti 1021

Annotation: excinuclease ABC subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 973 TIGR00630: excinuclease ABC subunit A" amino acids 7 to 945 (939 residues), 1443 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 133 to 239 (107 residues), 128.8 bits, see alignment E=1.5e-41 PF17755: UvrA_DNA-bind" amino acids 311 to 419 (109 residues), 126.6 bits, see alignment E=1.1e-40

Best Hits

Swiss-Prot: 91% identical to UVRA_AGRFC: UvrABC system protein A (uvrA) from Agrobacterium fabrum (strain C58 / ATCC 33970)

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P56899 at UniProt or InterPro

Protein Sequence (973 amino acids)

>SMc01235 excinuclease ABC subunit A (Sinorhizobium meliloti 1021)
MSELKTISIRGAREHNLKGIDLDLPRNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESL
SAYARQFLEMMQKPDVDQIDGLSPAISIEQKTTSRNPRSTVGTVTEIYDYLRLLFARVGV
PYSPATGLPIESQTVSQMVDRVLEFGEGTRLYMLAPLVRGRKGEYRKELAELMKKGFQRV
KVDGQFYEIADVPALDKKYKHDIDVVVDRVVVRPDIGTRLADSIETCLTLADGLAIAEFA
DRPLPPEETSAGGSANKSLNETHERVLFSEKFACPVSGFTIPEIEPRLFSFNNPFGACTT
CDGLGSQQKIDEALIVPEPNRTLRDGAIAPWAKSTSPYYNQTLEALGTVFGFKLGSRWSE
LSEEAQEAILHGTKDKITFHYQDGARSYNTTKTFEGIVPNLERRWKETDSAWAREEIERY
MSAAPCPACAGYRLKPEALAVKIHALHIGEVSEMSIRAARDWFEVLPEHLSTKQNEIAVR
ILKEIRERLRFLNDVGLEYLSLSRNSGTLSGGESQRIRLASQIGSGLTGVLYVLDEPSIG
LHQRDNARLLDTLRHLRDIGNTVIVVEHDEDAILTADYVVDIGPAAGIHGGEVIAEGTPS
DIMSNPKSLTGKYLSGELSVAVPGERRKPKKKKEVTVVGARANNLKNVTASIPLGVFTAV
TGVSGGGKSTFLIETLYKAAARRVMGARENPAEHDRIDGFEHIDKVIDIDQSPIGRTPRS
NPATYTGAFTPIRDWFAGLPEAKARGYQPGRFSFNVKGGRCEACQGDGVIKIEMHFLPDV
YVTCDVCHGKRYNRETLDVHFKGKSIADVLDMTVEEGVEFFAAVPAVRDKLVTLNQVGLG
YIKIGQQANTLSGGEAQRVKLAKELSKRSTGRTLYILDEPTTGLHFHDVAKLLEVLHELV
NQGNSVVVIEHNLEVIKTADWIIDFGPEGGDGGGEVIAQGTPEEVVKEPRSYTGQFLKEL
LERRPVKKVVAAE