Protein Info for SMc01207 in Sinorhizobium meliloti 1021
Annotation: S-adenosylmethionine--tRNA ribosyltransferase-isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to QUEA_RHIME: S-adenosylmethionine:tRNA ribosyltransferase-isomerase (queA) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K07568, S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC: 5.-.-.-] (inferred from 100% identity to smk:Sinme_1483)MetaCyc: 44% identical to S-adenosylmethionine--tRNA ribosyltransferase-isomerase (Clostridioides difficile)
RXN0-1342 [EC: 2.4.99.17]
Predicted SEED Role
"S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 5.-.-.-)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.-.-.-)
MetaCyc Pathways
- queuosine biosynthesis I (de novo) (3/4 steps found)
- queuosine biosynthesis III (queuosine salvage) (2/5 steps found)
KEGG Metabolic Maps
- Biosynthesis of steroids
- Carotenoid biosynthesis - General
- Lipopolysaccharide biosynthesis
- Pentose and glucuronate interconversions
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.4.99.17 or 5.-.-.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92PY5 at UniProt or InterPro
Protein Sequence (360 amino acids)
>SMc01207 S-adenosylmethionine--tRNA ribosyltransferase-isomerase (Sinorhizobium meliloti 1021) MRVDLFDFDLPENSIALRPASPRDSARMLVVRPDGAPVLEDRGVLDLPSFLRPGDALVFN DTKVIPAQLEGVRYRGEDISTPVSLTLHMRVAPSRWKAFARPARRLKPGDRISFGHGGSA CLLGSLEAVVEEKGDAGEVTLRFDLSGPSLDEAIMAVGHIPLPPYIASKRADDERDRTDY QTVYAREEGAVAAPTAGLHFTDRLFAKLDEGGIERYFVTLHVGAGTFLPVKADDTADHVM HEEIGHVDPVTAAKLNAVRERGGRIVCVGTTSLRLIESAAAEDGNIRPWSGATGIFITPG YRFRAVDMLMTNFHLPKSTLFMLVSAFAGLETMHAAYAHAIATGYRFYSYGDSSLLFRKD