Protein Info for SMc01143 in Sinorhizobium meliloti 1021

Annotation: heat-inducible transcription repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 359 TIGR00331: heat-inducible transcription repressor HrcA" amino acids 16 to 357 (342 residues), 322.2 bits, see alignment E=2.6e-100 PF01628: HrcA" amino acids 119 to 344 (226 residues), 195.9 bits, see alignment E=4.6e-62

Best Hits

Swiss-Prot: 100% identical to HRCA_RHIME: Heat-inducible transcription repressor HrcA (hrcA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03705, heat-inducible transcriptional repressor (inferred from 100% identity to smk:Sinme_0010)

Predicted SEED Role

"Heat-inducible transcription repressor HrcA" in subsystem Heat shock dnaK gene cluster extended

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92SK1 at UniProt or InterPro

Protein Sequence (359 amino acids)

>SMc01143 heat-inducible transcription repressor (Sinorhizobium meliloti 1021)
MVLRNPGTKGIASALDERSGEIFRRIVESYLESGEPLGSRNLSRLLPVSLSPASVRNVMS
DLEDLGLIYSPHVSAGRLPTQLGLRFFVDAFMQVGNLSPEERASIERQVHPGNRDRSVEN
LLTEASQMLSGMSRGAGLVITTKSDPVLKHVEFIRLAPTKALAVLVGEHDQVENRIIELP
AGITSAQLTEAANFVNAHLAGQTIPELRTQLEKVKETVRGELDALSQDLVERGLAIWSGS
EGDGQPARLIVRGRANLLEGLEGTDDIERLRMLFDDLEKKDSLIEILNLAESGPGVRIFI
GSENKLFSLSGSSLIVAPYRDSDDRIVGAVGVIGPTRLNYSRIVPMVDYTAQLMSRLSR