Protein Info for SMc01095 in Sinorhizobium meliloti 1021

Annotation: multidrug-efflux system transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1061 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 343 to 362 (20 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 395 to 416 (22 residues), see Phobius details amino acids 442 to 464 (23 residues), see Phobius details amino acids 472 to 499 (28 residues), see Phobius details amino acids 548 to 567 (20 residues), see Phobius details amino acids 876 to 896 (21 residues), see Phobius details amino acids 903 to 927 (25 residues), see Phobius details amino acids 933 to 956 (24 residues), see Phobius details amino acids 981 to 1001 (21 residues), see Phobius details amino acids 1010 to 1036 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 3 to 1037 (1035 residues), 1198.7 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1050 (1048 residues), 1192.6 bits, see alignment E=0 PF03176: MMPL" amino acids 300 to 517 (218 residues), 45.1 bits, see alignment E=1.1e-15 PF02355: SecD_SecF" amino acids 340 to 499 (160 residues), 23.9 bits, see alignment E=3.8e-09

Best Hits

KEGG orthology group: None (inferred from 82% identity to ara:Arad_3559)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92SH0 at UniProt or InterPro

Protein Sequence (1061 amino acids)

>SMc01095 multidrug-efflux system transmembrane protein (Sinorhizobium meliloti 1021)
MNFSRFFVDRPVFAGVLSVIIFVAGLIGMTGLPISEYPEVVPPQIVVRAQYPGANPAVIA
ETVATPLEEQINGVEGMLYMQSQATADGLMTLTVTFELGTDPDQAQQLVQNRVSQGEPRL
PEEVRRLGVTTVKSSPDLTLVVHLISPNGQYDINYLRNYGVLNVKDRLARVDGVGQVQIF
GGGDYSMRVWIDPEKAAERGLAASDIANAVRGQNVQAAAGVIGASPSVPGLDLQLSVNAQ
GRLKTPEDFADIVVKSGESGEITRLGDVARVEMGAADYSLRSLLDNKAAVGMGVFQAPGS
NAIQISENVHKVMAELKQTMPDGVDYEIVYDTTQFVRASIESVIHTLLEAIALVVVVVIV
FLQTWRASIIPLVAVPVSIVGTFAVMYVFGFSINALSLFGLVLAIGIVVDDAIVVVENVE
RNISQGLSPVQATYRAMQEVSGPIIAIALVLVAVFVPLAFITGLTGQFYRQFALTIAIST
VISALNSLTLSPALAALLLKDHHAPKDRLTRVMDGLFGWFFRGFNRFFGASSEAYGRGVG
GILTRKSLVMGVYVVLLGVTFVLFRAVPGGFVPAQDKQYLIGFAQLPDAATLDRSEDVIR
RMSEIALKHPGVEHAIAFPGLSINGFTNSSNSGIVFVSLKPFEERTTPELSGGAIAMQLN
QEFGAIQDAFIAMFPPPPVQGLGTTGGFKLQIEDRNGLGYRTLDDATKAVLAKAMAAPEL
AGLYSSFQINVPQLYADLDRTKARQLGVAVTDVFETLQIYLGSLYVNDFNAFGRTYSVRI
QADASYRSHADDIGKLKVRSQTGEMIPLSALLNVEQTVGAERAIRYNGFLAADINGGPAP
GFSSGQAQAAIERIAAETLPPGISYEWTDLTYQQILAGNSGILVFPLALLLVYLVLAAQY
ESLLLPIAIILIVPMGIMAALTGVWLTGGDNNVFTQIGLIVLVGLSAKNAILIVEFAREL
ELSGSNAVSAAIEASRLRLRPILMTSMAFIMGVVPLVTSTGAGAEMRSAMGVAVFAGMIG
VTAFGIFMTPVFYVLIRKLSGEKPLKHTGAHIEAPHLAPGE