Protein Info for SMc00992 in Sinorhizobium meliloti 1021

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 790 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 257 to 278 (22 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 335 to 504 (170 residues), 129.6 bits, see alignment E=4.8e-42 PF00990: GGDEF" amino acids 339 to 503 (165 residues), 132.1 bits, see alignment E=1.7e-42 PF00563: EAL" amino acids 531 to 756 (226 residues), 210.5 bits, see alignment E=2.4e-66

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMc00992)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92KK4 at UniProt or InterPro

Protein Sequence (790 amino acids)

>SMc00992 hypothetical protein (Sinorhizobium meliloti 1021)
MTLGKRALILIFPVVLAGYLLAALSVHVAQSRSIRALEHAKLSQRLEHAASVFQNEVRRS
RGALNALLSGNALRQYVAETDKKYRANALGVRLQESLTSLSDDPAGFISLAVFNSKLEAE
YYFENSWDPFAEIDPAQLDLARQLLNGSKLGDWSYVDSAGDRPRVIYSLFVDPVTFGRPA
PSNKANALLMQVAVQPDRFLRLQAPLKREYGAEIVLQPWPLAVTDDLSASVPLGPALHAT
LTVSDAHFEAQMLRQKVLLALGALAMSLFSIWLIIVLIRRFITGPIATLDTNVMAVMAGA
REEIAEVDEAGEIGRLTRNIREMHRQSLQSLQLVQRSSWTDTLTGISNRGRFNMLAAQAV
QEAVASGEKCSLLFIDIDNFKFVNDKHGHDVGDELLKTLATRIARDVEEITRRRGQEPAI
LARLSGDEFAVLLRSQPGDGAVQEICGAILALFSDGFELSGKRYPVTASIGVAACPDDAS
SVAELISNADAAMYQAKTAGKNRSARFSRALNDKRTRQRQIQDELRSLDPDEQFHLVYMP
IVDAGGKVTGCEALLRWHSPVLGHVTPDEFVPIAESSGLFTKIDWWVIDKAMSDCHQLKA
LFGPDTVLAINISSAELHSKSINEHFSDCLTRHGLEARSIDIELTETFAVQISDQLRLNM
EELRSKGFRLSIDDFGAGYTSVQQIIDYAADTIKLDRALVSNLAASRSLAVLKAVVALCH
AKEMTVVGEGVDTPEKLAMLTAAGCDRFQGYLISKPLPLAELAIWALSRVALAADKPADG
DGWPVAASRR