Protein Info for SMc00977 in Sinorhizobium meliloti 1021

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 593 PF02771: Acyl-CoA_dh_N" amino acids 38 to 155 (118 residues), 53.3 bits, see alignment E=1.1e-17 PF02770: Acyl-CoA_dh_M" amino acids 160 to 266 (107 residues), 46.8 bits, see alignment E=8.1e-16 PF00441: Acyl-CoA_dh_1" amino acids 287 to 452 (166 residues), 86.3 bits, see alignment E=7.2e-28 PF22924: ACOX_C_alpha1" amino acids 296 to 447 (152 residues), 28.9 bits, see alignment E=2.8e-10 PF08028: Acyl-CoA_dh_2" amino acids 303 to 445 (143 residues), 31.8 bits, see alignment E=4.8e-11 PF12806: Acyl-CoA_dh_C" amino acids 471 to 587 (117 residues), 68.2 bits, see alignment E=2.3e-22

Best Hits

KEGG orthology group: K00257, [EC: 1.3.99.-] (inferred from 100% identity to sme:SMc00977)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7, 1.3.99.-

Use Curated BLAST to search for 1.3.8.7 or 1.3.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92RJ6 at UniProt or InterPro

Protein Sequence (593 amino acids)

>SMc00977 acyl-CoA dehydrogenase (Sinorhizobium meliloti 1021)
MYKAPVEEIAFTLKHVAGMAEALDAGTFGELGEDLVDAILGEAGRFASEEVAPLGDAGDR
QGSRLVDGAVKTPEGWRELYRNWIAGGWNGLTAPEAFGGQNLPHMLHVAAMEMWNSGSMA
FALAPTLTMGAIEALEKHGTDALKATFLPKMVSGEWMGTMNLTEPHAGSDLGVLKTRAER
RDDGTYRILGQKIFITWGEHDFTDNIVHLVLARLPDAPAGTKGISLFLVPKFLVNEDGSL
GERNDVFCHSLEHKLGIHGSPTCTMIYGDGKFGREKGAIGYLVGEENRGLACMFTMMNNA
RLAVGMQGVAIAEAATQKAIAYAKERTQGRAPGWSGDGMSPIIEHPDIARTLLTMKALTQ
GSRAIAYACAHAVDMAHAAQGEDARQWQERSSLLTPIAKSFATDAGVDVASMGIQVHGGM
GFIEETGAARYLRDARIAPIYEGTNGIQAIDLVTRKLPLSDGAQVRGFIAELREVAAAVA
ASNREGFGETAARLDAAVADLEGATDWLLSRLRDGKLAEALAGATAYQRLFGLVLTGVYL
AKGGLAEAGDGGQDRRVALCRFAAENLLSETSALKDRVVNGAESLAAARSILD