Protein Info for SMc00943 in Sinorhizobium meliloti 1021

Annotation: TrpR binding protein WrbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01755: NAD(P)H:quinone oxidoreductase, type IV
  • amino acids 3 to 197 (195 residues), 349.5 bits, E=3.1e-109
• PF00258: Flavodoxin_1
  • amino acids 6 to 124 (119 residues), 40.2 bits, E=5.9e-14
• PF03358: FMN_red
  • amino acids 13 to 143 (131 residues), 51.4 bits, E=1.4e-17

Best Hits

Swiss-Prot: 100% identical to NQOR1_RHIME: NAD(P)H dehydrogenase (quinone) 1 (R01635) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03809, Trp repressor binding protein (inferred from 100% identity to smk:Sinme_1537)

MetaCyc: 61% identical to NAD(P)H:quinone oxidoreductase (Escherichia coli K-12 substr. MG1655)
NAD(P)H dehydrogenase (quinone). [EC: 1.6.5.2]

Predicted SEED Role

"Flavoprotein WrbA"

MetaCyc Pathways

• superpathway of photosynthetic hydrogen production (3/6 steps found)
• vitamin K-epoxide cycle (1/4 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.2

Use Curated BLAST to search for 1.6.5.2

Sequence Analysis Tools

See Q92PU3 at UniProt or InterPro

Protein Sequence (199 amino acids)

>SMc00943 TrpR binding protein WrbA (Sinorhizobium meliloti 1021)
MARVLVLYYSAYGHIETMAHAVAEGARSAGAEVAVKRVPELVPEDVAKASHFKLDQPAPV
ATVEELADYDAIIFGAGTRYGTVASQLRNFIDQTGGLWAKGKLVGKVGSAFTSSATQHGG
QESTILGLIPTMMHHGMVVVGLPYAFQGQMGVEEVKGGSPYGASTITGGDGSRQPSAVEL
EAARFQGAHVARIAAKLAD