Protein Info for SMc00918 in Sinorhizobium meliloti 1021
Annotation: ATP phosphoribosyltransferase regulatory subunit
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to HISZ_RHIME: ATP phosphoribosyltransferase regulatory subunit (hisZ) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K02502, ATP phosphoribosyltransferase regulatory subunit (inferred from 100% identity to smk:Sinme_0497)Predicted SEED Role
"ATP phosphoribosyltransferase regulatory subunit (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- L-histidine biosynthesis (10/10 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Histidine metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.4.2.17
Use Curated BLAST to search for 2.4.2.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92KL6 at UniProt or InterPro
Protein Sequence (379 amino acids)
>SMc00918 ATP phosphoribosyltransferase regulatory subunit (Sinorhizobium meliloti 1021) MPLINLPAFAGDLLADFERRNTLRVDTPVIQPAEPFLDMAGEDLRRRIFMTESETGESLC LRPEFTIPVCLRHIETATGTPQRYAYLGEVFRQRREGSSEFYQAGIEDLGDPDTAAADAR VVGDAMFVLANRLPGERLKVTLGDQSVFEAVIAACGLPGGWQKRLIHAFGDQKQLERLLA ALADPKSPGVFGHDVERVAALGMLEDEERLVAHIGETMKATGYSTNAGRSPRDIARRLKE KVELAAIRLDKEALGVMRAFLALDLPLADAPAALHRFAGKARLKIDDALALFDARVAALA RAGADPGLMRYRAAFGRPLDYYTGLVFEIGVEGTPAVLAGGGRFDRLLTLLGAREHIPAV GFSLWLDRIEQAIAAGRAE