Protein Info for SMc00696 in Sinorhizobium meliloti 1021

Annotation: 3-dehydroquinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01357: 3-dehydroquinate synthase
  • amino acids 22 to 369 (348 residues), 356.1 bits, E=1e-110
• PF00465: Fe-ADH
  • amino acids 24 to 191 (168 residues), 31.8 bits, E=1.1e-11
• PF13685: Fe-ADH_2
  • amino acids 26 to 194 (169 residues), 36.4 bits, E=7.8e-13
• PF01761: DHQ_synthase
  • amino acids 77 to 340 (264 residues), 322.9 bits, E=2e-100

Best Hits

Swiss-Prot: 100% identical to AROB_RHIME: 3-dehydroquinate synthase (aroB) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01735, 3-dehydroquinate synthase [EC: 4.2.3.4] (inferred from 100% identity to sme:SMc00696)

Predicted SEED Role

"3-dehydroquinate synthase (EC 4.2.3.4)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Type IV pilus (EC 4.2.3.4)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• 3-dehydroquinate biosynthesis I (2/2 steps found)
• superpathway of chorismate metabolism (38/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.4

Sequence Analysis Tools

See Q92ME7 at UniProt or InterPro

Protein Sequence (377 amino acids)

>SMc00696 3-dehydroquinate synthase (Sinorhizobium meliloti 1021)
MTSHVMPTAERKVRVDLAERSYDILIGPGLIAAAGKEIASRLKGRKMAVITDENVAPRYL
EPLMASLGESGIEAVSLILPAGEKTKSFEHLIPVCEAILGARIERNDAVIALGGGVIGDL
TGFAAGIVRRGSRFIQIPTSLLAQVDSSVGGKTGINSAHGKNLIGVFHQPDLVLADTAAL
DTLSPREFRAGYAEVAKYGLIDKPEFFEWLEKNWQAVFAGGPARIEAIAVSCQAKADVVA
ADERENGRRALLNLGHTFGHALEAATDYDSKRLVHGEGVAIGMVLAHEFSARMNLASPDD
ARRVEAHLKTVGLPTRLADIPGALPPADRLMEAIAQDKKVKGGKLTFILTRGIGQSFVAD
DVPSSEVLSFLTEKHPR