Protein Info for SMc00554 in Sinorhizobium meliloti 1021

Annotation: amidophosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01134: amidophosphoribosyltransferase
  • amino acids 22 to 474 (453 residues), 481.7 bits, E=1.5e-148
• PF13522: GATase_6
  • amino acids 86 to 215 (130 residues), 61.2 bits, E=1.6e-20
• PF13537: GATase_7
  • amino acids 103 to 219 (117 residues), 65 bits, E=9.4e-22
• PF00156: Pribosyltran
  • amino acids 297 to 397 (101 residues), 35.6 bits, E=8.8e-13

Best Hits

Swiss-Prot: 85% identical to PUR1_RHIEC: Amidophosphoribosyltransferase (purF) from Rhizobium etli (strain CFN 42 / ATCC 51251)

KEGG orthology group: K00764, amidophosphoribosyltransferase [EC: 2.4.2.14] (inferred from 100% identity to sme:SMc00554)

Predicted SEED Role

"Amidophosphoribosyltransferase (EC 2.4.2.14)" in subsystem De Novo Purine Biosynthesis (EC 2.4.2.14)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

• Glutamate metabolism
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.14

Sequence Analysis Tools

See Q92R10 at UniProt or InterPro

Protein Sequence (496 amino acids)

>SMc00554 amidophosphoribosyltransferase (Sinorhizobium meliloti 1021)
MTDLRSSEIHDELDGDTLHEECGVFGILGHPDAAALTALGLHALQHRGQEAAGIVTFDGR
QFYSERRMGLVGDHYTDPTTLAKLPGSMSIGHVRYSTTGETVLRNVQPLFAELQEGGIAI
AHNGNFTNGLTLRRQIIADGAICQSTSDTEVVLHLIARSKHVSSSDRFADAIAQVEGGYS
MLALTRTKLIAARDPNGIRPLVMGELDGKPIFCSETCALDIIGAKFVRDIENGEIVICEI
QPDGSITIDARKPQNPLPERLCLFEYVYFARPDSVVGGRNVYVARKNMGKNLAIEAPVEA
DVVVPVPDGGTPAAIGYAQESGIPFELGIIRNHYVGRTFIEPTQQIRAFGVKLKHSANRA
MIAGKRVVLVDDSIVRGTTSVKIVQMMREAGAREVHVRVASPMIFHPDFYGIDTPDRDKL
LANQHADLASMCRFIGADSLEFLSIDGLYRAVGGEKRDPQAPQFTDHYFTGDYPTRLLDQ
GAASNVRKLSVLASNG