Protein Info for SMc00450 in Sinorhizobium meliloti 1021
Annotation: protoheme IX farnesyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to COXX_RHIME: Protoheme IX farnesyltransferase (ctaB) from Rhizobium meliloti (strain 1021)
KEGG orthology group: K02301, protoheme IX farnesyltransferase [EC: 2.5.1.-] (inferred from 100% identity to sme:SMc00450)Predicted SEED Role
"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)
MetaCyc Pathways
- aerobic respiration I (cytochrome c) (3/4 steps found)
- arsenite to oxygen electron transfer (1/2 steps found)
- aerobic respiration II (cytochrome c) (yeast) (2/4 steps found)
- arsenite to oxygen electron transfer (via azurin) (1/3 steps found)
- Fe(II) oxidation (2/6 steps found)
KEGG Metabolic Maps
- Biosynthesis of terpenoids and steroids
- Carotenoid biosynthesis - General
- Methionine metabolism
- Oxidative phosphorylation
- Porphyrin and chlorophyll metabolism
- Riboflavin metabolism
- Terpenoid biosynthesis
- Tryptophan metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 1.9.3.1, 2.5.1.-
Use Curated BLAST to search for 1.9.3.1 or 2.5.1.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92RG8 at UniProt or InterPro
Protein Sequence (350 amino acids)
>SMc00450 protoheme IX farnesyltransferase (Sinorhizobium meliloti 1021) MTGNEQKPPVSAASPRRQAGVTRLFLPQQVQGTDMTVIGNHEVVGMEGAPRLSEASARDY FELLKPRVMSLVVFTAFAGLVLAPGHINPFIGFTAILCIAIGAGASGALNMWYDADIDAV MSRTAKRPIPAGKILPQEALAFGLTLSAFSVIILGLAVHWLAAGLLAFTIFFYVAIYTMW LKRSTPQNIVIGGAAGAFPPMIGWACVTGGVSVESIVLFLIIFLWTPAHFWALALFKMGD YGAVGVPMMPNVCGEATTKRQIVIYAVLTAVSGVCPTLLGFASLGYGAFATVMGLGFVWY SLGVLRMPEGDKRMVPAKKLFAFSIAYLFAIFSALLVDYAIARIWLGGIV