Protein Info for SMc00240 in Sinorhizobium meliloti 1021

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 430 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 60 to 83 (24 residues), see Phobius details amino acids 99 to 120 (22 residues), see Phobius details amino acids 132 to 157 (26 residues), see Phobius details PF01595: CNNM" amino acids 5 to 197 (193 residues), 175.5 bits, see alignment E=1.4e-55 PF00571: CBS" amino acids 212 to 268 (57 residues), 20.7 bits, see alignment 6.3e-08 amino acids 277 to 330 (54 residues), 29.4 bits, see alignment 1.3e-10 PF03471: CorC_HlyC" amino acids 347 to 424 (78 residues), 82.3 bits, see alignment E=3e-27

Best Hits

Swiss-Prot: 44% identical to Y260_SYNY3: UPF0053 protein sll0260 (sll0260) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K03699, putative hemolysin (inferred from 100% identity to sme:SMc00240)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92PR6 at UniProt or InterPro

Protein Sequence (430 amino acids)

>SMc00240 hypothetical protein (Sinorhizobium meliloti 1021)
MFELLVIFLLLLINAFFALSEMAIVSASKPLLRQMVKQGNRRAEAALKLAEDPGKFLSTV
QVGITLVGILAGAYGGATIAAKIAPFLNDIGWISPYGDTIAVALVVTLITFLSVVIGELI
PKQLALRNPEGLAMFVAGPMALLSRIVAPVVYIFETAASIAMRLMGMRPEDSDRVTEEEV
QAIMAEGVESGAIEKSEHEMLRRIIRLGDRNVKSIMTHRTEVSFIDVHDSLETIGQKIRQ
FGHSRYPVIDGPSGDVIGAVLAKEILNVAPAAPFNIRDYVREILTLPETASCLKALEAFK
SSSINMAMIVDEYGSTEGIITTADILEAIVGVIPSNYDNSEHALIRQRDDGSYLVDGRTP
IDEIHLQIGIDGIDADGDFETIAGFLVQQLRKTPEEGDTAEAHGYRFEVIDMDGRRIDKI
LVSRAGEALS