Protein Info for SMc00234 in Sinorhizobium meliloti 1021

Annotation: peptidyl-prolyl cis-trans isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 163 (163 residues), 125.4 bits, see alignment E=4.1e-40 PF13623: SurA_N_2" amino acids 2 to 139 (138 residues), 73.2 bits, see alignment E=4.3e-24 PF13145: Rotamase_2" amino acids 247 to 368 (122 residues), 93.5 bits, see alignment E=3.5e-30

Best Hits

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 100% identity to smk:Sinme_1563)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92PS1 at UniProt or InterPro

Protein Sequence (630 amino acids)

>SMc00234 peptidyl-prolyl cis-trans isomerase (Sinorhizobium meliloti 1021)
MLDSLRNAAQTRVVKGLLALLILSFMVWGGQTLMVPNTPNAVVTVGDVKVSASDFRLAYE
RQVALLSRQLGTPLSRQQAQAFGVENQVYAQLVAGAALDQLATDMNLGLSEDRLARLIGE
DPAFHGANGQFDRLTFSSVLRNAGLTEQDYINNRSQVAVRSQIVDALTDGYTAPKVLVDA
IGKYRHETRTIDYLLLSNANIDAVKTPGDDVLAPWFESRKANYRAPEYRKISYIKLEPED
LAAPDAVTSEELRADYEKRKESYRTPATRTVEQLTFPSREAADAAAAKLAAGTSFDDLVK
AEGKTSADVLLGDFTKERMPDAKIADAAFAVAQDGGTTPVVEGAFGPVILRVTNIRPDAV
RSFDEVKEELRKEIALDAAREQLVGLHDKIEDERAGGVSVKEIAEQLKLKLVTVDAVDAS
GKDQNGDEVKDLPEPRALLQEVFKADVGTDTLAVNIGRDGSAWFDVEEIIPARDRTLDEV
RDEVAADWTAEQQRAALAAKAKELKERIEKGAKLADIASELGLVVESKTGLTRATNDATL
SPAAVIAAFAGPNGHVANAPGIGGDGQVLMQVTAVEDQAPADALDNDSSQIEAIARASGD
DILDQMVSTLQTAYGVSINQSLAETALAQR