Protein Info for SMc00093 in Sinorhizobium meliloti 1021

Annotation: choline dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 549 TIGR01810: choline dehydrogenase" amino acids 4 to 531 (528 residues), 1013.3 bits, see alignment E=0 PF00732: GMC_oxred_N" amino acids 4 to 292 (289 residues), 210.2 bits, see alignment E=5.1e-66 PF05199: GMC_oxred_C" amino acids 384 to 520 (137 residues), 142.8 bits, see alignment E=1.7e-45

Best Hits

Swiss-Prot: 100% identical to BETA_RHIME: Oxygen-dependent choline dehydrogenase (betA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_0657)

MetaCyc: 100% identical to choline dehydrogenase (Sinorhizobium meliloti Rm2011)
Choline dehydrogenase. [EC: 1.1.99.1]

Predicted SEED Role

"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.1

Use Curated BLAST to search for 1.1.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P54223 at UniProt or InterPro

Protein Sequence (549 amino acids)

>SMc00093 choline dehydrogenase (Sinorhizobium meliloti 1021)
MQADFVIIGSGSAGSALAYRLSEDGRNSVIVLEFGGSDVGPFIQMPAALAWPMSMNRYNW
GYLSEPEPNLNNRRITAPRGKVIGGSSSINGMVYVRGHSEDFNRWEELGAQGWAYADVLP
YYKRMEHSHGGEEGWRGTDGPLHVQRGPVKNPLFHAFIEAGKEAGFEVTEDYNGSKQEGF
GLMEQTTWRGRRWSAASAYLRPALKRPNVELIRCFARKIVIENGRATGVEIERGGRIEVV
KANREVIVSASSFNSPKLLMLSGIGPAAHLKEMGIDVKVDRPGVGQNLQDHMEFYFQQVS
TKPVSLYSWLPWFWQGVAGAQWLFFKRGLGISNQFESCAFLRSAPGVKQPDIQYHFLPVA
ISYDGKAAAKSHGFQVHVGYNLSKSRGNVSLRSSDPKADPVIRFNYMSHPEDWEKFRHCV
RLTREIFGQKAFDLYRGPEIQPGEKVQTDEEIDGFLREHLESAYHPCGTCKMGAKDDPMA
VVDPETRVIGVDGLRVADSSIFPHITYGNLNAPSIMTGEKSADHILGRQPLARSNQEPWI
NPRWAVSDR