Protein Info for SMc00059 in Sinorhizobium meliloti 1021

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 525 transmembrane" amino acids 36 to 56 (21 residues), see Phobius details amino acids 62 to 82 (21 residues), see Phobius details PF00512: HisKA" amino acids 239 to 308 (70 residues), 70.8 bits, see alignment E=8.2e-24 PF02518: HATPase_c" amino acids 355 to 464 (110 residues), 101.4 bits, see alignment E=4e-33

Best Hits

Swiss-Prot: 100% identical to Y1002_RHIME: Uncharacterized sensor-like histidine kinase R01002 (R01002) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K11357, two-component system, cell cycle sensor histidine kinase DivJ [EC: 2.7.13.3] (inferred from 100% identity to smk:Sinme_0711)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q52969 at UniProt or InterPro

Protein Sequence (525 amino acids)

>SMc00059 sensor histidine kinase (Sinorhizobium meliloti 1021)
MAGRWTSLVDEAAAPWLPRGGLGSAIARHDFRRLRAVAAVSLTALPIVPLALTLALPVSA
ALPAGAALWASASLLAAAAAIAGGREFPTDGEVEFAPAPELPDLNAAYDLFAGLVTVHDT
RGHVLSVHGRDASEYLKLMRDPHGRGFIEQIHVSDRIAFLRAIDSLRLDSERSAVDIRLE
RTSADGPQFAHIYCEMTPLRDAEGNLLAIVAQSRDVSEEARLQAEAAAKAAHAESANDAK
TRFLAAVSHELRTPLNAILGFSDVLAGEYFGKLENDRQREYVSLIHQSGTHLLSVVNTML
DMSKIEAGRYELLLEPFRVAEAIAACEAMLSHQAREKGVRLTSRVTRSVGEINADQRAFQ
QILINLIGNAIKFTDRGGLVTVDAALEGNMLKLTVSDTGIGIAADKLQMLGQPFVQIQND
YTRRYEGTGLGLSLVKGLAELHGGDVSIRSAEGEGTVIVVTIPSDASGAAERQCADAPVT
VEFPPRLKQHADGKREAGVPALSEALHTGEIGREGGHGAAQAKTA