Protein Info for SMc00012 in Sinorhizobium meliloti 1021

Annotation: cytochrome C oxidase assembly protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 198 transmembrane" amino acids 15 to 36 (22 residues), see Phobius details PF04442: CtaG_Cox11" amino acids 35 to 179 (145 residues), 196.7 bits, see alignment E=1.1e-62

Best Hits

Swiss-Prot: 100% identical to COXZ_RHIME: Cytochrome c oxidase assembly protein CtaG (ctaG) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02258, cytochrome c oxidase subunit XI assembly protein (inferred from 100% identity to smk:Sinme_0615)

Predicted SEED Role

"Cytochrome oxidase biogenesis protein Cox11-CtaG, copper delivery to Cox1" in subsystem Biogenesis of cytochrome c oxidases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92RG6 at UniProt or InterPro

Protein Sequence (198 amino acids)

>SMc00012 cytochrome C oxidase assembly protein (Sinorhizobium meliloti 1021)
MADNGQADRKERSNGVIVGTCLAFVAGMIGMAYAAVPLYDMFCRVTGYNGTTQRVEQASD
LILDEKIKVTFDANVAAGLPWEFVPVQRDIDVRIGETVQIMYRAKNLASTPTTGQATFNV
TPMAAGAYFNKVQCFCFTETTLEPGEEMEMPVVFFVDPEIVKPVETQGIKTLTLSYTFYP
REPSKPVAQVKAKAENKL