Protein Info for SMc00009 in Sinorhizobium meliloti 1021

Annotation: cytochrome C oxidase subunit II protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 294 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 50 to 71 (22 residues), see Phobius details amino acids 92 to 113 (22 residues), see Phobius details PF02790: COX2_TM" amino acids 26 to 112 (87 residues), 87.8 bits, see alignment E=4.3e-29 TIGR02866: cytochrome c oxidase, subunit II" amino acids 37 to 261 (225 residues), 201.9 bits, see alignment E=4.1e-64 PF00116: COX2" amino acids 125 to 252 (128 residues), 158.5 bits, see alignment E=6.6e-51

Best Hits

KEGG orthology group: K02275, cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 100% identity to sme:SMc00009)

Predicted SEED Role

"Cytochrome c oxidase polypeptide II (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92RH0 at UniProt or InterPro

Protein Sequence (294 amino acids)

>SMc00009 cytochrome C oxidase subunit II protein (Sinorhizobium meliloti 1021)
MKNKAYAVLAALACLLFASSAFADKPVDWQTNFQAAATGIMEEITWFEHYTLWFIIPITL
FVLLLLVIVVVKFRESANPVPSRTSHNTLIEVVWTVGPVIVLLFLAIPSFQLLTAQLTPP
ENPDLTVKATGNQWYWSYEYEVGESPLSFDSLLLKDEDRAGLGKEDKAQYPRLLAVDNEV
VVPVGKTVRLLVTAADVIHAFAMPAFGVKIDAVPGRLNETWFKADREGLYYGQCSELCGK
DHAYMPIAVRVVAQDKYDAWLAAAATNVGEANKALMASVDGAAKAVDVADNAAQ