Protein Info for SMc00007 in Sinorhizobium meliloti 1021

Annotation: chorismate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00033: chorismate synthase
  • amino acids 10 to 360 (351 residues), 405.7 bits, E=7.8e-126
• PF01264: Chorismate_synt
  • amino acids 10 to 355 (346 residues), 423.3 bits, E=2.4e-131

Best Hits

Swiss-Prot: 100% identical to AROC_RHIME: Chorismate synthase (aroC) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01736, chorismate synthase [EC: 4.2.3.5] (inferred from 100% identity to sme:SMc00007)

Predicted SEED Role

"Chorismate synthase (EC 4.2.3.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 4.2.3.5)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of chorismate metabolism (38/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.5

Sequence Analysis Tools

See Q92RH3 at UniProt or InterPro

Protein Sequence (365 amino acids)

>SMc00007 chorismate synthase (Sinorhizobium meliloti 1021)
MSHNTFGHLFRVTTWGESHGPALGCVVDGCPPGIRFTLAEVQAWLDKRKPGQSRFVTQRR
EDDLVKVLSGVMLDDDGETMISTGTPISMMIENTDQRSKDYSEIAKRYRPGHADYTYDAK
YGIRDYRGGGRSSARETAARVAAGAIARKVVPGLVVRGALVQIGKHRIDRSNWDWAEVNN
NPFFAPDPAIVPVWEEYLDGIRKAGSSIGAVVEVVAEGVPAGIGAPIYAKLDQDIAANLM
SINAVKGVEIGNGFAAAEISGEENADEMRIGAQGEPVFLSNNAGGILGGIATGQPVVARF
AIKPTSSILTERRSIDSDGKEVDVRTKGRHDPCVGIRAVPIGEAMLACAIADHYLRDRGQ
TGRLK