Protein Info for SMa2371 in Sinorhizobium meliloti 1021

Annotation: cytosine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 PF07969: Amidohydro_3" amino acids 40 to 400 (361 residues), 193.3 bits, see alignment E=1.2e-60 PF01979: Amidohydro_1" amino acids 49 to 398 (350 residues), 50.7 bits, see alignment E=1.7e-17

Best Hits

KEGG orthology group: K01485, cytosine deaminase [EC: 3.5.4.1] (inferred from 100% identity to sme:SMa2371)

MetaCyc: 45% identical to cytosine deaminase monomer (Klebsiella pneumoniae)
Cytosine deaminase. [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]

Predicted SEED Role

"Cytosine deaminase (EC 3.5.4.1)" (EC 3.5.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.1

Use Curated BLAST to search for 3.5.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92XH0 at UniProt or InterPro

Protein Sequence (432 amino acids)

>SMa2371 cytosine deaminase (Sinorhizobium meliloti 1021)
MFDLIIRNANLPDGRQGFDIGLAGGKIAAIEKSITASPGEEIDAAGRLVSPPFCDPHFHM
DATLSLGLPRMNISGTLLEGISLWGELRPLLTKEALVERALRYCDLAVTQGLLYIRSHVD
TSDPRLVTAEALLEVKEQVAPYIELQLVAFPQDGYFRAPGGVASLERALDMGIGIVGGIP
HFERTMEDGARSVEALCRLAADRGLPVDMHCDETDDPMSRHIETLAAETVRFGLKGRVAG
SHLTSMHSMDNYYVSKLISLMAEAEINVIPNPLINIMLQGRHDTYPKRRGMTRVRELMAA
DLNVSFGHDCVMDPWYSMGSGDMLEVAHMAIHVAQMAGIEDKCKIFDAITVNSAKTMGLE
GYGLDIGCKADLVVLQAADVTEALRLKPNRLFVIKAGKVIARTAPRVGELFLSGRPASID
MGRDYVPPVLQR