Protein Info for SMa2295 in Sinorhizobium meliloti 1021
Annotation: penicillin-binding protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to sme:SMa2295)Predicted SEED Role
"Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton or Flagellum in Campylobacter or Peptidoglycan Biosynthesis (EC 2.4.1.129)
MetaCyc Pathways
- peptidoglycan biosynthesis I (meso-diaminopimelate containing) (11/12 steps found)
- peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
- peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
- peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
- peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)
- peptidoglycan maturation (meso-diaminopimelate containing) (3/12 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.4.1.129
Use Curated BLAST to search for 2.4.1.129
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92XK8 at UniProt or InterPro
Protein Sequence (443 amino acids)
>SMa2295 penicillin-binding protein (Sinorhizobium meliloti 1021) MLPHYKQQAVIDSGLAAVGFRPENQRIYPNGSLAAHILGAVDIDNFGIAGIEKWIDANWL ADLRGAGLALKGRDLQPVELSIDLRVQYAMEQELGKAVKKFGAAAGAGLLLDVTNGEILA LASYPAFDPNNPVDAFKPDRINRVTAGVFEMGSTFKALTTAMALESGRFDLESVVDASRP LSFGRQRIHDYRGKYRPLTVPEAFIHSSNIVMAKMAMTLGPEALRTFLGRFGVLSQLATE LPESAAPLRPSSWSEVTTATVSFGHGIAVTPLQASMAVAALANGGRLIRPTFIKDSPVSE RTIAESLLSANTSEAIRHLLRLNAAVGSATKADVPGYVIGGKTGTAEKVVQGRYSKVLNV TSFMGIVPADNPRYLLLTLLDEPRGLAETYGNRTSGWNAVPLGGALLHRILPMLLKPVFP SPSSAEAVPVATGEPSVDDSSSD