Protein Info for SMa2063 in Sinorhizobium meliloti 1021

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 347 PF07536: HWE_HK" amino acids 153 to 234 (82 residues), 86.8 bits, see alignment E=1.4e-28 PF07568: HisKA_2" amino acids 153 to 215 (63 residues), 36.2 bits, see alignment E=5.2e-13

Best Hits

KEGG orthology group: None (inferred from 99% identity to smk:Sinme_6803)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92XW3 at UniProt or InterPro

Protein Sequence (347 amino acids)

>SMa2063 sensor histidine kinase (Sinorhizobium meliloti 1021)
MDATDSPLDWVLTMAPYRRDAEHLEALLAQNGLPVRRAEGVEELTALLEQGPGVLVATHE
ALNPEVLEVIRRYLIDQPEWSEMPLVILLDRAVPQARVRAELSAAWPRSRQLYYQRPVTT
LELLSGIQSILLARLRQRDIRDRIEREIELRRELNHRVKNILASISSIFQMTRRRAVSLD
EFAEDFAGRLAALANVHSAVFQADGEAVEFSSVVELTFSPYRVRGTDRLVFTGPTVLLRP
DAATTLALCLHELATNALKYGALSTPEGRVSLQWSVSEEADLLSLEWVESGGPSVSEPSR
SGYGTRYIRSALSSQFGTPPVILFHPQGLRCIVSGPLSRVSPRQPEV