Protein Info for SMa2037 in Sinorhizobium meliloti 1021

Annotation: Oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01315: Ald_Xan_dh_C
  • amino acids 29 to 136 (108 residues), 98.7 bits, E=3.7e-32
• PF02738: MoCoBD_1
  • amino acids 166 to 404 (239 residues), 227.5 bits, E=2.1e-71
• PF20256: MoCoBD_2
  • amino acids 441 to 689 (249 residues), 203.1 bits, E=1e-63

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa2037)

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (11/11 steps found)
• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• guanosine nucleotides degradation III (4/4 steps found)
• inosine 5'-phosphate degradation (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• ureide biosynthesis (6/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (2/7 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (2/10 steps found)
• theophylline degradation (1/9 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Sequence Analysis Tools

See Q92XX3 at UniProt or InterPro

Protein Sequence (750 amino acids)

>SMa2037 Oxidoreductase (Sinorhizobium meliloti 1021)
MNFDPSHSKRSFSSVGTRPIRPDGVDKVTGRARYGADFNMPGQLVGRILRSPHAHAIIRK
IDTLKAAQLPGVKAVLTAADLPDLTDGDAAMYDILDNCMARKKALYDGHAVAAVAAIDAR
TAKQALKLIEVEYELLPHVTDVDQAFAPDAPLINDTIFTTGVDPKPDRPSNVSMRSQFGH
GDVDAGMARADFVVERTFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
QLLGMDASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPT
SATSIDVKIGALKDGTIIAADATLRYSCGPYAGAWAEVGAMTAFACYKLENVRTVGYEVL
VNRPKTAAYRAPSAPMAAFAVESAIDELAKKVGMNPIDFRIRNAAQEGTKASYGPVYGPI
GIGPTLEAVKNHPHMKAPLGRNQGRGMACGFWFNFGGQTCTDLNIGMDGTVSLAVGTVDV
GGSRASLSLVAAEELGIDYSQVRTVIADTSSLGYNDMTDGSRGTFSSSMATISAARNAIK
ILRERAAQMWDIPVEDVTWEKGHAVAKGETHGNLPKLSLKEIAAASGTTGGPIAGHSEIV
ADGAGVSFATHICDIEVDPETGATKVLRYTVVQDAGKAVHPTYVEGQYQGGAAQGIGWAL
NEEYIYGNDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
AVANAVSNAVGVRMLHIPMSPPRILAALEA