Protein Info for SMa1801 in Sinorhizobium meliloti 1021

Annotation: Reverse transcriptase, maturase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 419 TIGR04416: group II intron reverse transcriptase/maturase" amino acids 16 to 381 (366 residues), 421 bits, see alignment E=1.9e-130 PF00078: RVT_1" amino acids 72 to 291 (220 residues), 142.2 bits, see alignment E=1.9e-45 PF08388: GIIM" amino acids 317 to 391 (75 residues), 64.8 bits, see alignment E=5.7e-22

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa1801)

Predicted SEED Role

"Retron-type RNA-directed DNA polymerase (EC 2.7.7.49)" (EC 2.7.7.49)

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.49

Use Curated BLAST to search for 2.7.7.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q925Z6 at UniProt or InterPro

Protein Sequence (419 amino acids)

>SMa1801 Reverse transcriptase, maturase (Sinorhizobium meliloti 1021)
MTSESTTDKPFRIEKRRVYEAYKAVKANRGAAGVDGQTLEIFEKDLAANLYKIWNRMSSG
TYFPPPVRAVSIPKKAGGERVLGVPTVSDRIAQMVVKQMIEPDLDSLFLPDSYGYRPGKS
ALDAVGVTRQRCWKYDWVLEFDIKGLFDNLPHDLLLKAVRKDVKCNWALLYIERWLTAPM
EKNGEVIERSRGTPQGGVVSPILANLFLHYAFDLWMTRTHPDLPWCRYADDGLVHCQSEQ
QAEALKVELSSRLAACGLQMHPTKTKIVYCKDQRRREAYPNVTFDFLGYQFRPRRVANTQ
WDEFFCGYTPAVSPTALKSMRATIKSLNIPRQTPGTLAEIAKQLNPLLRGWIAYYGRYSR
SALSTLADYVNQKLRAWIRRKFKRFQSHKTRASLFLRKLARENPGLFVHWKAFGTNTFT