Protein Info for SMa1667 in Sinorhizobium meliloti 1021

Annotation: ArcD1 arginine/ornithine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 475 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 40 to 63 (24 residues), see Phobius details amino acids 85 to 108 (24 residues), see Phobius details amino acids 124 to 144 (21 residues), see Phobius details amino acids 151 to 176 (26 residues), see Phobius details amino acids 200 to 220 (21 residues), see Phobius details amino acids 232 to 254 (23 residues), see Phobius details amino acids 283 to 310 (28 residues), see Phobius details amino acids 331 to 351 (21 residues), see Phobius details amino acids 357 to 379 (23 residues), see Phobius details amino acids 396 to 414 (19 residues), see Phobius details amino acids 420 to 438 (19 residues), see Phobius details amino acids 451 to 469 (19 residues), see Phobius details TIGR00905: transporter, basic amino acid/polyamine antiporter (APA) family" amino acids 1 to 475 (475 residues), 516.9 bits, see alignment E=2.6e-159 PF13520: AA_permease_2" amino acids 8 to 414 (407 residues), 178.1 bits, see alignment E=3e-56 PF00324: AA_permease" amino acids 18 to 391 (374 residues), 59.7 bits, see alignment E=2.3e-20

Best Hits

Swiss-Prot: 52% identical to ARCD_PSEAE: Arginine/ornithine antiporter (arcD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03758, arginine:ornithine antiporter (inferred from 100% identity to smk:Sinme_6102)

Predicted SEED Role

"Arginine/ornithine antiporter ArcD" in subsystem Arginine Deiminase Pathway or Arginine and Ornithine Degradation or Polyamine Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92YG7 at UniProt or InterPro

Protein Sequence (475 amino acids)

>SMa1667 ArcD1 arginine/ornithine antiporter (Sinorhizobium meliloti 1021)
MTSTAQKLSLASLAALVVGSMVGAGIFSLPRTFGDATGPFGAIVAWCIAGAGIFTLAHVF
RVLAERKSDLDAGVYAYANAGFGDYAGFLSVLGYWLVGCIADVSYWVLIKATLGAFFPIF
GDGNTIAAVLVSSVALWGFHFMILRGIKEAAAINTVVTVAKIVPILIFIVILLGAFETDL
FRSNFWGGADMPEASLFEQIRATMLVTVFVFIGVEGASVYSRYARKRSDVGVATTLGFVV
VLGLMVLVTLLPYGALERPEIAAMRQPSMASVLESIVGPWGSVFVSAGLIVSVLGAYLAW
SLICVEVLFCAAKNGDMPSVLARENSNSVPAAALWLSNGVIQLFLISTLFSEDAFRLMVN
LTSAMVLIPYLLVAAYGFLVAKRGETYNIRPKERFRDLILAGAATVYTAFMIYAGGLKFL
LLSAILYALGTALFFYARREQKKPLFSPREWLVFIAVVAGCLVGIYGLVTGSITI