Protein Info for SMa0579 in Sinorhizobium meliloti 1021

Annotation: guanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 819 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 334 to 357 (24 residues), see Phobius details PF00672: HAMP" amino acids 359 to 405 (47 residues), 38.8 bits, see alignment 1.4e-13 PF12860: PAS_7" amino acids 428 to 544 (117 residues), 75 bits, see alignment E=8.2e-25 PF00211: Guanylate_cyc" amino acids 584 to 766 (183 residues), 78.7 bits, see alignment E=6.6e-26

Best Hits

KEGG orthology group: None (inferred from 100% identity to sme:SMa0579)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92ZZ5 at UniProt or InterPro

Protein Sequence (819 amino acids)

>SMa0579 guanylate cyclase (Sinorhizobium meliloti 1021)
MFDRLGVRGRLLFAFFGISAFAVLATVGALYAFLELSQVLERVTERRAPSALASLELSRH
AERVAATAPAFLASTSRARHSEVSAAIGSEMARLEELLAALKGATLSSGVVSEIEDAVVG
LRRNLHALDDLVTVRLAAVARKEELLRRLSATTNASQRLVAPGILVMNSKVPRWRAATAD
AVTTPEAEAAATRDLARAIAAYIPQQTAQREIAAINDTLLQAAVAPTPGDLSLISFPLRR
SIETLESVTPEFDEQLRKRFQQLVDQFEALIDGQRSIPNARNEELAVVAEGEKLVVENDK
LSRKLTLAVDRLVAAAKGDIAEAGSEAATVRRYGTGVVLGSALLSLLSSVLIVWLYVDRN
LLARLTGLSHSMLAIAAGDLRVPLPQTRGDEIGRMAKALRVFRDTAIEVEEKNLRTVAEA
RQRLIDAIESISEGFAFYDSEDRLLVCNSRYRDILYPGMDDTVVSGTHFEAIIRAAAERG
LIEDAIGREQEWLAERLEAHRNPTGTLLQQRGPDRWIQISERRISGGGTVAVYSDITELK
RREQDLSEKSVALEALSAKLAKYLAPQVYNSIFSGKQDVRIESRRKKLTICFSDIAAFTE
TTDKMESEELTQLLNQYLTEMSKIALSFGATIDKYVGDAILMFFGDPETRGIREDAIACV
SMALAMQERMGELGETWRSVGIEMPLRCRIGIHTDYCTVGNFGSEDRMDYTIIGGAVNLA
ARLEEEAAPGSVLISYETFAQVKDLIHCEETGRVQIRGIAYPVATYRVVDFKANLTKSCN
AIRTELPHLRLEAEPELMSTGEREVAITALRETLDRLRR