Protein Info for SMa0402 in Sinorhizobium meliloti 1021

Annotation: GntR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 243 TIGR02018: histidine utilization repressor" amino acids 10 to 238 (229 residues), 277.3 bits, see alignment E=4.4e-87 PF00392: GntR" amino acids 11 to 74 (64 residues), 64.8 bits, see alignment E=6.8e-22 PF07702: UTRA" amino acids 96 to 232 (137 residues), 91.9 bits, see alignment E=5.2e-30

Best Hits

Swiss-Prot: 47% identical to HUTC_PSEAE: Histidine utilization repressor (hutC) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 100% identity to sme:SMa0402)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q930I2 at UniProt or InterPro

Protein Sequence (243 amino acids)

>SMa0402 GntR family transcriptional regulator (Sinorhizobium meliloti 1021)
MNTLSDSASPLYEKVKDFVLGNIGSGKWARNSRLPSENELVSALGVSRMTVHRALRELTS
EGHLRRIQGVGTFVAPPRPRSTLIEISNIITEIKTRGSRHRAEVVVLERIARPEPELLLA
FEFETVKPVDHSVVIHFENDLPVQLEERYVNPNLVSGYIDQDFAAVATYDYLQNATPLTE
VEHLISALPANAEQARLLNVRPGDCCLILHRKTWTGPVVATVNTFTYVGSRYSLGSRYLH
GGK