Protein Info for SMa0185 in Sinorhizobium meliloti 1021

Annotation: transmembrane-transport protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 514 transmembrane" amino acids 16 to 43 (28 residues), see Phobius details amino acids 55 to 75 (21 residues), see Phobius details amino acids 84 to 102 (19 residues), see Phobius details amino acids 109 to 134 (26 residues), see Phobius details amino acids 146 to 168 (23 residues), see Phobius details amino acids 174 to 193 (20 residues), see Phobius details amino acids 205 to 224 (20 residues), see Phobius details amino acids 231 to 250 (20 residues), see Phobius details amino acids 270 to 295 (26 residues), see Phobius details amino acids 307 to 326 (20 residues), see Phobius details amino acids 338 to 358 (21 residues), see Phobius details amino acids 364 to 387 (24 residues), see Phobius details amino acids 408 to 428 (21 residues), see Phobius details amino acids 475 to 496 (22 residues), see Phobius details PF07690: MFS_1" amino acids 22 to 413 (392 residues), 171.4 bits, see alignment E=2.6e-54 PF00083: Sugar_tr" amino acids 69 to 195 (127 residues), 35.8 bits, see alignment E=4.8e-13

Best Hits

KEGG orthology group: K08167, MFS transporter, DHA2 family, methyl viologen resistance protein SmvA (inferred from 100% identity to smk:Sinme_5399)

Predicted SEED Role

"possible transmembrane-transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q930U7 at UniProt or InterPro

Protein Sequence (514 amino acids)

>SMa0185 transmembrane-transport protein (Sinorhizobium meliloti 1021)
MADNIHTPEQASRREWVGLCVLSIACLIYSMDLSVLFLAVPAIVADLDPSASQLLWINDI
YGFMVAGFLVTMGTLGDRIGRRRVLLMGAFAFGVASAFAAFSNTPGQLILARALLGIAGA
TIAPSTLSLIVNLFKNEAERNRAISIWGTAFALGGLVGPLIGGILLQYFHWGSVFLINIP
VMLLLLAVAPFLLPEYKNNDAGRLDLLSVVLSLATVLPIIYGFKHMAADGFQLAQIVYIG
LGLLVGLLFVRRQRRLSDPLVDLALFRVPAFTASLMVNLAGVFFVFGVFLFQNLFLQLVL
GLSPLEAALWSAPSALVFAVMSFQAYRFTNRFGPVRTVLGGLLVNAAGAAAMAIAAYAES
LIGILGSSMIIGFGFVPVVLTTTGLIVGTAPPERAGSASAISETSAEFGGALGIAVLGSL
ATLIYRMAMNRADLSSLNPVQAEAVSATLAGAVETARSMPGSTSAVWLETAKSGFSLGFA
ICCVVATVTLLLLAIVARRVYATAHIDESTLAPH