Protein Info for SM_b21654 in Sinorhizobium meliloti 1021

Updated annotation (from data): ABC transporter for Lactose, permease component 2
Rationale: Specific phenotypes on Beta-Lactose. Not important for arabinose utilization but there is no other clear arabinose tranpsorter so who knows (KEGG_correct)
Original annotation: lactose ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 47 to 70 (24 residues), see Phobius details amino acids 76 to 95 (20 residues), see Phobius details amino acids 107 to 128 (22 residues), see Phobius details amino acids 135 to 155 (21 residues), see Phobius details amino acids 180 to 205 (26 residues), see Phobius details amino acids 238 to 259 (22 residues), see Phobius details PF00528: BPD_transp_1" amino acids 90 to 267 (178 residues), 70.7 bits, see alignment E=6.9e-24

Best Hits

Swiss-Prot: 76% identical to LACG_RHIRD: Lactose transport system permease protein LacG (lacG) from Rhizobium radiobacter

KEGG orthology group: K10190, lactose/L-arabinose transport system permease protein (inferred from 100% identity to sme:SM_b21654)

Predicted SEED Role

"Glycerol-3-phosphate ABC transporter, permease protein UgpE (TC 3.A.1.1.3)" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization (TC 3.A.1.1.3)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92XF8 at UniProt or InterPro

Protein Sequence (272 amino acids)

>SM_b21654 ABC transporter for Lactose, permease component 2 (Sinorhizobium meliloti 1021)
MNGFGRFAAMAATYGFLGLMAFLSVFPFIWMVLGATNSSIDIIKGKLLPGAAFATNVANF
FTLVNVPLVFWNSAKIAIVATVLTLAVSSLAGYGFEMFRSRRRERVYRAMLLTLMIPFAA
LMIPLFVMMGKAGLINTHLAVVLPSIGSAFVIFYFRQSTKAFPSELRDAAKVDGLKEWQI
FLFIYVPVMRSTYAAAFVIVFMTAWNNYLWPLIVLQTNETKTITLVISSLASAYYPDYGV
VMVGTILATLPTLAVFFFMQRQFVQGMLGSVK