Protein Info for SM_b21588 in Sinorhizobium meliloti 1021

Annotation: sugar uptake ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 505 PF00005: ABC_tran" amino acids 24 to 173 (150 residues), 111 bits, see alignment E=7.5e-36 amino acids 275 to 428 (154 residues), 76.3 bits, see alignment E=3.8e-25

Best Hits

Swiss-Prot: 60% identical to YTFR_ECO57: Uncharacterized ABC transporter ATP-binding protein YtfR (ytfR) from Escherichia coli O157:H7

KEGG orthology group: K02056, simple sugar transport system ATP-binding protein [EC: 3.6.3.17] (inferred from 100% identity to sme:SM_b21588)

MetaCyc: 60% identical to galactofuranose ABC transporter putative ATP binding subunit (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-491 [EC: 7.5.2.9]; 7.5.2.9 [EC: 7.5.2.9]

Predicted SEED Role

"Putative sugar ABC transport system, ATP-binding protein YtfR (EC 3.6.3.17)" (EC 3.6.3.17)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.17

Use Curated BLAST to search for 3.6.3.17 or 7.5.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UR5 at UniProt or InterPro

Protein Sequence (505 amino acids)

>SM_b21588 sugar uptake ABC transporter ATP-binding protein (Sinorhizobium meliloti 1021)
MQTSSDNILSATRIEKGFPGTKALDRVDFHLRRGEVHALLGENGAGKSTLIKCLTGAYRR
DGGSMLLDGAEADPRDTFDAQRLGIGTVYQEVNLLPNLTVAENLFLGRQPRRFGMVDTRT
MNRKARELLAEYELDIDVTRDLASYSVAIQQVVAIARAVDLSGKVLILDEPTASLDAHEV
EMLFRIVRRLKERGLGIIFITHFLEQVYAISDRITVLRNGQLVGTRNAADLDRRELIAMM
IGRELATEIHSAHSDAVAGEPRYRFRNFGRRGKIDPFDLDVRAGEVVGMAGLLGSGRTET
AEILFGAHRADSGTAEIDGRSVDLSSPRAAIRQKFGFCPEDRKTAGIVGDLSVRENIVLA
LQARRGWTRPIPRAEQNRLADHYIRALDIRTADREKPIRLLSGGNQQKAILARWLATEPE
LLILDEPTRGIDVGAHAEIIRLIESLREKGMSLIVISSEIEELVAYSTRVVVLRDHAHVA
ELDGAQLTAHRIVEAIAATNGREAP