Protein Info for SM_b21560 in Sinorhizobium meliloti 1021

Annotation: two component sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 420 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 137 to 155 (19 residues), see Phobius details PF00672: HAMP" amino acids 155 to 204 (50 residues), 37.7 bits, see alignment 3.2e-13 PF00512: HisKA" amino acids 211 to 269 (59 residues), 36.6 bits, see alignment E=5.8e-13 PF02518: HATPase_c" amino acids 306 to 413 (108 residues), 93.5 bits, see alignment E=1.8e-30

Best Hits

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_4712)

Predicted SEED Role

"MISCELLANEOUS; Not classified regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92UT7 at UniProt or InterPro

Protein Sequence (420 amino acids)

>SM_b21560 two component sensor histidine kinase (Sinorhizobium meliloti 1021)
MRSRLFLKIYLTLLASLAAVAVASAAFVWLGQGEEESGWQSQRARFVAALIPPDMDNRTV
EATIERFSRAFDADIAVYDPRGRLIASGGSPIPRDILDQPWRHGPGNFHTMVTELPDGRT
VAARMERPLRPSGRNPLAYLALIAGVIGLAAYPVVRHLTRRLERLRVGVDAWGKGDFVVR
VPEDGSDEVAAVAKSFNRAADQVERLIKSHRALLANASHELRSPLARLRMAIDLYEQAPN
DDRKQEIIRNLSELDTLIEEILLASRLDHVEKLDALESVDLLALVSEEGARNDVEVFGMP
AIVACDARLLRRLVRNLLQNALHHGGPPVTAAVAQADDAAILRVRDHGPGIADSERHRVF
EPFYRPSGRSEAAGGWGLGLALVRQIAERHGGAVSYESPPDGGACFVVTLPVQSKPVRDR