Protein Info for SM_b21520 in Sinorhizobium meliloti 1021

Annotation: two-component response regulator protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 PF00072: Response_reg" amino acids 7 to 117 (111 residues), 75.2 bits, see alignment E=6.9e-25 PF08281: Sigma70_r4_2" amino acids 150 to 196 (47 residues), 37.3 bits, see alignment 2.6e-13 PF00196: GerE" amino acids 154 to 207 (54 residues), 74.7 bits, see alignment E=5.2e-25

Best Hits

Swiss-Prot: 37% identical to NREC_STAAW: Oxygen regulatory protein NreC (nreC) from Staphylococcus aureus (strain MW2)

KEGG orthology group: None (inferred from 100% identity to smk:Sinme_4386)

Predicted SEED Role

"two-component response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92TZ3 at UniProt or InterPro

Protein Sequence (219 amino acids)

>SM_b21520 two-component response regulator protein (Sinorhizobium meliloti 1021)
MMTGIRVAVVDDHPLFREGVTRSLSEIDGFEIVAEGGSRDEAVAIAQSLNPDVMLLDISM
PGGGLNAVPAILSVAPSQKIVMLTVSEANDDVAAALKEGAKGYILKGIGARALAEVIRTV
ASGESYVAPTLSAKLLTGQLANSAPAKSNLVAELTRREQEVLHLVASGMSNKQIARKLDL
HEKTVKHHMTQIMAKLDVANRTEAAMVLRDALDWRPVSQ