Protein Info for SM_b21488 in Sinorhizobium meliloti 1021

Annotation: cytochrome o ubiquinol oxidase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 669 transmembrane" amino acids 26 to 48 (23 residues), see Phobius details amino acids 68 to 89 (22 residues), see Phobius details amino acids 113 to 137 (25 residues), see Phobius details amino acids 154 to 175 (22 residues), see Phobius details amino acids 200 to 223 (24 residues), see Phobius details amino acids 241 to 264 (24 residues), see Phobius details amino acids 285 to 308 (24 residues), see Phobius details amino acids 320 to 342 (23 residues), see Phobius details amino acids 353 to 377 (25 residues), see Phobius details amino acids 391 to 413 (23 residues), see Phobius details amino acids 425 to 450 (26 residues), see Phobius details amino acids 467 to 488 (22 residues), see Phobius details amino acids 502 to 528 (27 residues), see Phobius details amino acids 598 to 617 (20 residues), see Phobius details amino acids 620 to 640 (21 residues), see Phobius details TIGR02843: cytochrome o ubiquinol oxidase, subunit I" amino acids 12 to 656 (645 residues), 1137.8 bits, see alignment E=0 PF00115: COX1" amino acids 66 to 514 (449 residues), 497.8 bits, see alignment E=1.4e-153

Best Hits

Swiss-Prot: 67% identical to CYOB_ECOL6: Cytochrome bo(3) ubiquinol oxidase subunit 1 (cyoB) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02298, cytochrome o ubiquinol oxidase subunit I [EC: 1.10.3.-] (inferred from 84% identity to avi:Avi_6215)

MetaCyc: 67% identical to cytochrome bo3 subunit 1 (Escherichia coli K-12 substr. MG1655)
RXN-21817 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit I (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92U26 at UniProt or InterPro

Protein Sequence (669 amino acids)

>SM_b21488 cytochrome o ubiquinol oxidase subunit I (Sinorhizobium meliloti 1021)
MFSDPDFLKLIFGRLTLDAIPYHEPILVVTFLAVALGGIALIGLITYYRFWGTLWRDWLT
SVDHKKIGIMYIILALVMLLRGFSDAIMMRLQQAMAFGGSEGYLPPHHYDQVFTAHGVIM
IFFMAMPFVTGLMNFVVPLQIGARDVSFPFLNNFSFWMTTAGAIIIMLSLFVGEFARTGW
LAYPPLSGADYSPGVGVDYYVWGLQIAGIGTTLSGINLIATIVKMRAPGMTMMKMPVFTW
TSLCTNVLIVATFPVLTATLALLTLDRYAGTNFFTNDLGGNPMMYVNLIWIWGHPEVYIL
ILPAFGIFSEVVATFCGKRLFGYASMVYATVVITILSYIVWLHHFFTMGSGASVNAFFGI
TTMIISIPTGAKMFNWLFTMYRGRIRYEVPMLWTIGFMVTFVLGGMTGVLLAVPPADFVL
HNSLFLIAHFHNVIIGGVVFGLMAGVVYWFPKAFGFRLDPFWGKMSFWFWLTGFYFAFMP
LYVLGLMGVTRRVSQFEDPSLQIWFVIAAFGAFLIALGILSMLIQLVVSFVRREELRDTT
GDPWDGRTLEWSTASPPPDYNFAFTPLVHDQDSWWDMKKRGHSRPLVGFKPIHMPKNTGT
GVILGAISVVFAFAMVWYMWWLVILSFVAMAAIAIGHTFNYDRDFHIPANVVADTEGKRT
EALAPEVQA