Protein Info for SM_b21465 in Sinorhizobium meliloti 1021

Annotation: HlyD family protein secretion protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 439 signal peptide" amino acids 1 to 39 (39 residues), see Phobius details TIGR01843: type I secretion membrane fusion protein, HlyD family" amino acids 17 to 439 (423 residues), 471.8 bits, see alignment E=1.1e-145 PF00529: CusB_dom_1" amino acids 33 to 396 (364 residues), 67.1 bits, see alignment E=2.2e-22 PF13533: Biotin_lipoyl_2" amino acids 61 to 104 (44 residues), 28.6 bits, see alignment 1.9e-10 PF16576: HlyD_D23" amino acids 270 to 379 (110 residues), 36.6 bits, see alignment E=6.1e-13 PF13437: HlyD_3" amino acids 291 to 394 (104 residues), 56 bits, see alignment E=1.2e-18

Best Hits

Swiss-Prot: 100% identical to PRSE_RHIME: Type I secretion system membrane fusion protein PrsE (prsE) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K02022, (no description) (inferred from 100% identity to sme:SM_b21465)

Predicted SEED Role

"protein secretion protein, HlyD family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7ANN5 at UniProt or InterPro

Protein Sequence (439 amino acids)

>SM_b21465 HlyD family protein secretion protein (Sinorhizobium meliloti 1021)
MKGWLQQHKPTARRSLSRHLIGVSVLALALVAGVGGWAATTELSSAIVAGGVVIVDDNVK
KVQHLTGGIVGELLVKEGDRVEAGQVLIRLDGTTVRANLAIIESTLAQFYARRARLQAER
MGAASFEIEEDLAEFIPGTAAAKLIEGEQRLFASRRSALSGMKGQLDSRKAQLADEVEGL
TVQLNAIEEALKLIAEELTGVDSLFGQGLVPMQRVTTLKRQRAELEGGRGRHIAARAQAR
GKSSEIDLQILQLDEDRRSEISKELTDVEAKIAEYEERRTAATDQLRRLDITAPLSGRIY
QLAIHTVNGVINPGETLMLVVPEAEDLTVEAKVATHDIDQIRVGQSVEIRFSAFNQRTTP
EVEAEVVTVAPDLVTDERTGASYYPLRIRPKAESLAKLKGLSLYPGMPAEVFIKIADRTV
ISYLTKPLTDQMRHAFRED