Protein Info for SM_b21422 in Sinorhizobium meliloti 1021

Annotation: sugar uptake ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 498 PF00005: ABC_tran" amino acids 21 to 170 (150 residues), 84.8 bits, see alignment E=4.6e-28 amino acids 270 to 424 (155 residues), 47.4 bits, see alignment E=1.5e-16

Best Hits

Swiss-Prot: 38% identical to RBSA2_RUBXD: Ribose import ATP-binding protein RbsA 2 (rbsA2) from Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)

KEGG orthology group: K02056, simple sugar transport system ATP-binding protein [EC: 3.6.3.17] (inferred from 100% identity to sme:SM_b21422)

Predicted SEED Role

"ABC transporter ATP-binding protein"

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.17

Use Curated BLAST to search for 3.6.3.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92U87 at UniProt or InterPro

Protein Sequence (498 amino acids)

>SM_b21422 sugar uptake ABC transporter ATP-binding protein (Sinorhizobium meliloti 1021)
MTADFLAVRGIRKSFGQIEVLHGVDLDLPAGTITALLGENGAGKSTFVRILAGDHMPDGG
TISVDGAVASFRGVGDARAAGIRLIAQEIADAPTLSVAENILLGAWPTRAGLVDYRSMRE
LARQALEMLGTELPLEAKVASLRLGERQIIEIARSTIGASKCIIFDEATAALSDAEARKL
FQLIRRLAGRGVAILYITHRLDEVFALADRVCVLRDGRVSLDSAAGDVTQDQVIEAMVGR
AVAYARHAVPPSTDAPPVLKATGLGSASFSDVSFALRPGEILGVYGKVGSGVQELSSSLV
GARAFDEGTLYVEGSPRHFRHPADAIAAGIGHLSADRAADGLLRTMTLAENLSAPSWGRL
ARRGFVNRRKLRQAYCRWHRTLHIKAAASGEQLITELSGGNQQKVLLGRWLEAGSKILVL
SEPTRGVDVGARQEIYRVLAGLAAKGHAIVVATSDYEDITAVASRALVMVRGRMVAEIPY
ERISTEALTEAAGGGVHA