Protein Info for SM_b21300 in Sinorhizobium meliloti 1021

Annotation: deoxyribose-phosphate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00126: deoxyribose-phosphate aldolase
  • amino acids 69 to 292 (224 residues), 141.5 bits, E=1.3e-45
• PF01791: DeoC
  • amino acids 70 to 282 (213 residues), 67.3 bits, E=8.1e-23

Best Hits

Swiss-Prot: 60% identical to DEOC_HUMAN: Deoxyribose-phosphate aldolase (DERA) from Homo sapiens

KEGG orthology group: K01619, deoxyribose-phosphate aldolase [EC: 4.1.2.4] (inferred from 100% identity to sme:SM_b21300)

Predicted SEED Role

"Deoxyribose-phosphate aldolase (EC 4.1.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 4.1.2.4)

MetaCyc Pathways

• superpathway of purine deoxyribonucleosides degradation (6/7 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (5/6 steps found)
• 2-deoxy-α-D-ribose 1-phosphate degradation (2/3 steps found)
• 2-deoxy-D-ribose degradation I (2/3 steps found)

KEGG Metabolic Maps

• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 4.1.2.4

Use Curated BLAST to search for 4.1.2.4

Sequence Analysis Tools

See Q92VA4 at UniProt or InterPro

Protein Sequence (334 amino acids)

>SM_b21300 deoxyribose-phosphate aldolase (Sinorhizobium meliloti 1021)
MEDLALKSAAVHPAGAGHNWPRNDGVELDLSWVLDQRVNLSAAERRVQTLPGRRTVKKDA
QAAWLLKAVTCIDLTTLNGDDTAERVKRLCAKARQPVRQDILDALGMGDRGITTGAICVY
HRFVSTAVEALEGSGIPVAAVSTGFPAGLVPHDVKLREIKASVADGAREIDIVITREHVL
TGNWQALYDEMRDFRAACGDAHVKAILATGDLKTLRNVARASLVCMMAGADFIKTSTGKE
GVNATLLVTLAMLRMIRAYEERTGIKVGYKPAGGISVAKDVLNYQFLMKEELGREWLEPD
LFRVGASSLLADIERQLEHHVSGAYSALNRHPIG